Technology Process of methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate
There total 5 articles about methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iron; ammonium chloride;
In
tetrahydrofuran; ethanol; water;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Lawessons reagent / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere
2: ethanol / 4 h / 80 °C / Inert atmosphere
3: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / -20 - 20 °C / Inert atmosphere
5: ammonium chloride; iron / ethanol; tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere; Reflux
With
Lawessons reagent; water; iron; ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.05.006
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / -20 - 20 °C / Inert atmosphere
3: ammonium chloride; iron / ethanol; tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere; Reflux
With
water; iron; ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.05.006