2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid

Base Information

• Chemical Name: 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid
• CAS No.: 1448265-42-6
• Molecular Formula: C₂₂H₁₉FN₄O₃S₂
• Molecular Weight: 470.548
• Mol file: 1448265-42-6.mol

Synonyms:2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid

Chemical Property of 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid

There total 7 articles about 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H21FN4O3S2 → 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid (1448265-42-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.05.006

Reference yield:

methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate (1210761-69-5) → 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid (1448265-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 55 - 60 °C / Inert atmosphere

1.2: 20 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With water; lithium hydroxide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.ejmech.2013.05.006

Reference yield:

4-nitrobenzamide (619-80-7) → 2-(2-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-4-carboxamido)-3-methylbutanoic acid (1448265-42-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: Lawessons reagent / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

2.1: ethanol / 4 h / 80 °C / Inert atmosphere

3.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / -20 - 20 °C / Inert atmosphere

5.1: ammonium chloride; iron / ethanol; tetrahydrofuran; water / 4 h / 80 °C / Inert atmosphere; Reflux

6.1: ethanol / 55 - 60 °C / Inert atmosphere

6.2: 20 h / 80 °C / Inert atmosphere

7.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With Lawessons reagent; water; iron; ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.05.006

upstream raw materials:

methyl 2-(4-(4-aminophenyl)thiazolidine-2-carboxamido)-3-methylbutanoate

4-nitrobenzamide

4-nitrothiobenzamide

ethyl 2-(4-nitrophenyl)thiazole-4-carboxylate

Refernces