m-PEG9-Tos

Base Information

• Chemical Name: m-PEG9-Tos
• CAS No.: 82217-01-4
• Molecular Formula: C₂₄H₄₂O₁₁S
• Molecular Weight: 538.657
• Mol file: 82217-01-4.mol

Synonyms:2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate

Chemical Property of m-PEG9-Tos

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

m-PEG9-Tos 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: m-PEG9-Tos is a PEG linker containing a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of m-PEG9-Tos

There total 1 articles about m-PEG9-Tos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

octaethylene glycol monomethyl ether (25990-96-9) + p-toluenesulfonyl chloride (98-59-9) → 2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate (82217-01-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 10 ℃; for 6h;

Reference yield: 93.1%

4-bromo-3,5-dimethylphenol (7463-51-6) + 2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate (82217-01-4) → C25H43BrO9 (869718-83-2)

Guidance literature:

4-bromo-3,5-dimethylphenol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate; With 18-crown-6 ether; In tetrahydrofuran; at 0 ℃; Heating / reflux;

Reference yield: 86.0%

4-benzyloxy-2'-hydroxy-5-methoxy-biphenyl-3-carbaldehyde (1134103-74-4) + 2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate (82217-01-4) → 4-benzyloxy-5-methoxy-2'-[2-(2-{2-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-biphenyl-3-carbaldehyde

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 12h; Reflux;

DOI:10.1016/j.bmcl.2008.12.063

upstream raw materials:

octaethylene glycol monomethyl ether

p-toluenesulfonyl chloride

Downstream raw materials:

25-azido-2,5,8,11,14,17,20,23-octaoxapentacosane

1,4-bis(chloromethyl)-2-methoxy-5-(octaethoxymethoxy)benzene

C₆₂H₉₀O₂₀

C₂₅H₄₃BrO₉

Refernces

• 1、 -. "CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS". Page/Page column 169. . Retrieved 2021/10/30.
• 2、 -. "A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS". Page/Page column 163. . Retrieved 2020/08/22.