MPEG8-N3

Base Information

• Chemical Name: MPEG8-N3
• CAS No.: 869718-80-9
• Molecular Formula: C₁₇H₃₅N₃O₈
• Molecular Weight: 409.48
• Mol file: 869718-80-9.mol

Synonyms:25-azido-2,5,8,11,14,17,20,23-octaoxapentacosane

Chemical Property of MPEG8-N3

Chemical Property:

• Refractive Index: 1.4590 to 1.4630

Purity/Quality:

98%,99%, ^*data from raw suppliers

25-Azido-2,5,8,11,14,17,20,23-octaoxapentacosane >90.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG8-azide is a monodisperse PEG linker containing an azide group. It isreactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Technology Process of MPEG8-N3

There total 6 articles about MPEG8-N3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene) (352439-36-2) + methyl iodide (74-88-4) → 25-azido-2,5,8,11,14,17,20,23-octaoxapentacosane (869718-80-9)

Guidance literature:

α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene); With sodium hydride; In tetrahydrofuran; mineral oil; for 1h;

methyl iodide; In tetrahydrofuran; mineral oil; for 0.75h;

DOI:10.1021/acs.joc.0c00331

Reference yield: 86.4%

2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate (82217-01-4) → 25-azido-2,5,8,11,14,17,20,23-octaoxapentacosane (869718-80-9)

Guidance literature:

With sodium azide; In water; N,N-dimethyl-formamide; at 58 ℃;

Reference yield:

C18H38O11S (1059588-19-0) → 25-azido-2,5,8,11,14,17,20,23-octaoxapentacosane (869718-80-9)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; for 20h; Reflux; Inert atmosphere;

upstream raw materials:

2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate

octaethylene glycol monomethyl ether

C₁₈H₃₈O₁₁S

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

Downstream raw materials:

2,5,8,11,14,17,20,23-octaoxapentacosan-25-amine

Refernces

• 1、 -. "CROSSLINKED POLYMER NANO-ASSEMBLIES AND USES THEREOF". . . Retrieved 2019/04/08.