352439-36-2 Usage
Description
Alpha-Azido-omega-hydroxy octa(ethylene glycol), also known as Azide-PEG8-alcohol, is a versatile click chemistry reagent that features an azide (N3) group and a terminal hydroxyl group. The azide group is highly reactive with alkyne, BCN, and DBCO through click chemistry, resulting in a stable triazole linkage. The hydroxyl (OH) group allows for further derivatization or substitution with other functional groups, making it a valuable building block in various applications.
Uses
Used in Polymer Synthesis:
Alpha-Azido-omega-hydroxy octa(ethylene glycol) is used as a structural unit for the synthesis of oligo and poly(ethylene glycol) derivatives, which are essential components in dendrimers, hydrogels, surface modifiers, self-assembling systems, and molecular crosslinkers.
Used in Hydrogel Synthesis:
In the biomedical industry, alpha-Azido-omega-hydroxy octa(ethylene glycol) is used as a precursor for the synthesis of strain-stiffening hydrogels through the self-assembly of oligomers and biodegradable tetra-PEG hydrogels for drug delivery systems.
Used in Bioconjugation and Drug Delivery:
Alpha-Azido-omega-hydroxy octa(ethylene glycol) is utilized as a heterobifunctional oligo(ethylene glycol) linker for bioconjugation and targeted drug delivery, enhancing the specificity and efficiency of therapeutic agents.
Used in Carbon Nanotube Dispersions:
In the materials science industry, alpha-Azido-omega-hydroxy octa(ethylene glycol) is used in the preparation of synthetic amphiphiles for programmed pH-dependent dispersions of carbon nanotubes (CNTs), improving their solubility and integration into various applications.
Used in Glycoprotein Detection:
Alpha-Azido-omega-hydroxy octa(ethylene glycol) is employed in the selective detection of glycoproteins through allosteric click-imprinting, using a self-assembled monolayer developed from the oligomer.
Used in Quantum Dot Micelles:
In the field of nanotechnology, alpha-Azido-omega-hydroxy octa(ethylene glycol) is used in the preparation of bioactivated quantum dot micelles containing fluorescent nanocrystals, which have potential applications in imaging and sensing.
Check Digit Verification of cas no
The CAS Registry Mumber 352439-36-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,4,3 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 352439-36:
(8*3)+(7*5)+(6*2)+(5*4)+(4*3)+(3*9)+(2*3)+(1*6)=142
142 % 10 = 2
So 352439-36-2 is a valid CAS Registry Number.
352439-36-2Relevant articles and documents
Supramolecular compound nano-carrier as well as preparation method and application thereof
-
Paragraph 0086; 0102, (2021/08/14)
The invention discloses a supramolecular compound nano-carrier as well as a preparation method and application thereof, and relates to the technical field of polymer chemistry and biological detection engineering. According to the supramolecular compound nano-carrier disclosed by the invention, a two-dimensional nanosheet supramolecular structure system generated by self-assembly is driven by an anion induction effect, and a supramolecular compound nano-carrier is of a single-layer nanosheet supramolecular structure constructed by a highly-oriented one-dimensional nanorod. A hydrophobic perylene group part is used as a skeleton part for constructing the highly-oriented one-dimensional nanorod, and the charge density of a single-layer nanosheet can be regulated and controlled. The surface of the water-soluble multivalent hydrophilic part can be loaded with DNAzyme deoxyribozyme for specific detection of heavy metal ions through electrostatic interaction, and the water-soluble multivalent supramolecular compound nano sensor is constructed. Based on a fluorescence change mechanism caused by specific cutting of heavy metal ions, The fluorescence detection of the heavy metal ions in food and biological tissues is realized, and the detection effect of the heavy metal ions is greatly enhanced.
PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof
-
Paragraph 0024-0026; 0044-0045, (2020/06/17)
The invention provides a PROTAC compound represented by formula I and used for targeted degradation of IDO1, and a pharmaceutically acceptable salt, a hydrate or a solvate thereof. In the formula I, Xrepresents -CH2 or -C = O, Y represents -CH2 or -C= O, and n is a natural number from 2 to 9. The PROTAC compound for targeted degradation of the IDO1 has efficient activity of targeted degradation of the IDO1 protein.
Monodisperse polyethylene glycol “brushes” with enhanced lipophilicity, and thermo and plasma stability
Li, Yu,Wang, Xuemeng,Chen, Yongping,Yang, Zhigang,Jiang, Zhong-Xing
supporting information, p. 1895 - 1898 (2019/05/02)
A convenient strategy was developed for highly branched and multifunctionalized peptidic monodisperse polyethylene glycol “brushes”, which exhibit remarkable physicochemical and biological properties and potential as versatile biomaterials.
