868594-52-9 Usage
Description
FMoc-NH-8(ethylene glycol)-acetic acid, also known as Fmoc-NH-PEG8-CH2COOH, is a PEG linker that features an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer enhances solubility in aqueous media, and the Fmoc group can be deprotected under basic conditions to reveal the free amine for subsequent conjugations. The terminal carboxylic acid is capable of reacting with primary amine groups in the presence of activators like EDC or HATU to form a stable amide bond.
Uses
Used in Bioconjugation:
FMoc-NH-8(ethylene glycol)-acetic acid serves as a bioconjugation agent for attaching various biomolecules, such as peptides, proteins, or other amine-containing compounds, to its Fmoc-protected amine. The PEG spacer improves the solubility and stability of the resulting conjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, FMoc-NH-8(ethylene glycol)-acetic acid is utilized as a component in drug delivery systems. The PEG spacer can enhance the solubility and bioavailability of drugs, while the terminal carboxylic acid allows for the attachment of drug molecules through stable amide bonds.
Used in Diagnostics:
FMoc-NH-8(ethylene glycol)-acetic acid can be employed in the development of diagnostic tools, where the PEG spacer and terminal carboxylic acid facilitate the attachment of imaging agents or other diagnostic molecules to biomolecules for improved detection and imaging.
Used in Material Science:
In the field of material science, FMoc-NH-8(ethylene glycol)-acetic acid can be used to create functionalized surfaces or materials by attaching specific biomolecules or other compounds to surfaces through the terminal carboxylic acid, enabling various applications such as sensors or biocompatible materials.
Check Digit Verification of cas no
The CAS Registry Mumber 868594-52-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,5,9 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 868594-52:
(8*8)+(7*6)+(6*8)+(5*5)+(4*9)+(3*4)+(2*5)+(1*2)=239
239 % 10 = 9
So 868594-52-9 is a valid CAS Registry Number.
868594-52-9Relevant articles and documents
Monodisperse polyethylene glycol “brushes” with enhanced lipophilicity, and thermo and plasma stability
Li, Yu,Wang, Xuemeng,Chen, Yongping,Yang, Zhigang,Jiang, Zhong-Xing
, p. 1895 - 1898 (2019/05/02)
A convenient strategy was developed for highly branched and multifunctionalized peptidic monodisperse polyethylene glycol “brushes”, which exhibit remarkable physicochemical and biological properties and potential as versatile biomaterials.
