Thiazolo[5,4-h]quinoline (8CI,9CI)

Base Information

• Chemical Name: Thiazolo[5,4-h]quinoline (8CI,9CI)
• CAS No.: 233-94-3
• Molecular Formula: C₁₀H₆N₂S
• Molecular Weight: 186.237
• Hs Code.: 2934999090
• Mol file: 233-94-3.mol

Synonyms:3-Thia-1,9-diaza-3H-benz[e]indene

Chemical Property of Thiazolo[5,4-h]quinoline (8CI,9CI)

Chemical Property:

• Melting Point: 158 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 363.0±15.0 °C(Predicted)
• PKA: 0.81±0.40(Predicted)
• PSA: 54.02000
• Density: 1.394±0.06 g/cm3(Predicted)
• LogP: 2.84450

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiazolo[5,4-h]quinoline (8CI,9CI)

There total 5 articles about Thiazolo[5,4-h]quinoline (8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-4-nitrobenzothiazole (6973-51-9) → thiazolo[5,4-h]quinoline (233-94-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₂; aqueous HNO₃; H₃PO₄ / anschliessend Einwirkung von Kupfer in wss. HCl

2: red phosphorus; aqueous HI; acetic acid

3: as2O₅; concentrated H₂SO₄

With phosphorus; arsenic(V) oxide; phosphoric acid; sulfuric acid; hydrogen iodide; nitric acid; acetic acid; sodium nitrite;

DOI:10.1002/hlca.19400230141

Reference yield:

N-(2-nitrophenyl)thiourea (51039-84-0) → thiazolo[5,4-h]quinoline (233-94-3)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine; CHCl₃ / Behandeln des Reaktionsprodukts mit wss. Bisulfit

2: NaNO₂; aqueous HNO₃; H₃PO₄ / anschliessend Einwirkung von Kupfer in wss. HCl

3: red phosphorus; aqueous HI; acetic acid

4: as2O₅; concentrated H₂SO₄

With phosphorus; arsenic(V) oxide; chloroform; phosphoric acid; sulfuric acid; hydrogen iodide; bromine; nitric acid; acetic acid; sodium nitrite;

DOI:10.1002/hlca.19400230141

Reference yield:

2-chloro-benzothiazol-4-ylamine (855283-00-0) → thiazolo[5,4-h]quinoline (233-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: red phosphorus; aqueous HI; acetic acid

2: as2O₅; concentrated H₂SO₄

With phosphorus; arsenic(V) oxide; sulfuric acid; hydrogen iodide; acetic acid;

DOI:10.1002/hlca.19400230141

upstream raw materials:

4-aminobenzothiazol

glycerol

2-chloro-benzothiazol-4-ylamine

2-amino-4-nitrobenzothiazole