5-nitro-2,3-dimethoxytoluene

Base Information

• Chemical Name: 5-nitro-2,3-dimethoxytoluene
• CAS No.: 78312-28-4
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.191
• Mol file: 78312-28-4.mol

Synonyms:5-nitro-2,3-dimethoxytoluene

Chemical Property of 5-nitro-2,3-dimethoxytoluene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-nitro-2,3-dimethoxytoluene

There total 7 articles about 5-nitro-2,3-dimethoxytoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,2-dimethoxy-3-methylbenzene (4463-33-6) → 5-nitro-2,3-dimethoxytoluene (78312-28-4)

Guidance literature:

With nitric acid; at -10 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(01)96630-X

Reference yield:

2-methoxy-3-methylphenol (18102-31-3) → 5-nitro-2,3-dimethoxytoluene (78312-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: alkali

2: nitric acid; glacial acetic acid / Reinigung durch Reduktion zu 2.5-Dioxy-3-methoxy-toluol und Oxydation mit Ferrichlorid

With nitric acid; acetic acid;

Reference yield:

2-methyl-6-methoxyphenol (2896-67-5) → 5-nitro-2,3-dimethoxytoluene (78312-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: alcoholic KOH-solution / 110 - 120 °C / im Rohr

2: nitric acid; glacial acetic acid / Reinigung durch Reduktion zu 2.5-Dioxy-3-methoxy-toluol und Oxydation mit Ferrichlorid

With potassium hydroxide; nitric acid; acetic acid;

upstream raw materials:

1,2-dimethoxy-3-methylbenzene

nitric acid

acetic acid

2-methoxy-3-methylphenol

Downstream raw materials:

2,3-dimethoxy-5-nitrobenzoic acid

3-Methyl-4,5-dimethoxyaniline

2-methoxy-6-methyl-4-nitrophenol

2,3-dimethoxy-5,6-dinitro-toluene

Refernces