2-Amino-5-ethylphenol

Base Information

• Chemical Name: 2-Amino-5-ethylphenol
• CAS No.: 182499-90-7
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• European Community (EC) Number: 809-140-4
• DSSTox Substance ID: DTXSID40405691
• Nikkaji Number: J2.935.993H
• Wikidata: Q82210376
• Mol file: 182499-90-7.mol

Synonyms:2-amino-5-ethylphenol;182499-90-7;2-amino-5-ethyl-phenol;PHENOL, 2-AMINO-5-ETHYL-;Phenol, 2-amino-5-ethyl- (9CI);SCHEMBL454989;DTXSID40405691;VBCFPAKCBOGUBW-UHFFFAOYSA-N;1-amino 2-hydroxy 4-ethylbenzene;MFCD06408244;2-Amino-5-ethyl-phenol, AldrichCPR;AKOS006337173;MB03784;AS-77101;CS-0342384;FT-0709391;n-(p-(difluoromethoxy)phenyl)-anthranilicaci;D82162

Chemical Property of 2-Amino-5-ethylphenol

Chemical Property:

• Boiling Point: 254.829 °C at 760 mmHg
• Flash Point: 107.917 °C
• PSA: 46.25000
• Density: 1.116 g/cm³
• LogP: 2.11800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-ethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1)N)O

Technology Process of 2-Amino-5-ethylphenol

There total 4 articles about 2-Amino-5-ethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-ethyl-2-nitrophenol (101664-28-2) → 4-amino-3-hydroxy(ethyl)benzene (182499-90-7)

Guidance literature:

palladium-carbon; In methanol;

Reference yield:

neuromelanin → 2-amino-4-ethylphenol (94109-11-2) + 4-amino-3-hydroxyphenylethylamine (104083-77-4) + 4-amino-3-hydroxy(ethyl)benzene (182499-90-7) + 4-amino-3-hydroxyphenylacetic acid (133331-79-0) + 3-amino-tyrosine (3387-86-8) + α-Amino-β-(3-hydroxy-4-aminophenyl)propionic Acid (88686-28-6) + 3-amino-4-hydroxyphenylethylamine (81666-88-8) + 4-hydroxy-3-amino-phenylacetic acid (38196-08-6)

Guidance literature:

With hydrogen iodide; hypophosphorous acid; In water;

DOI:10.1111/jnc.13237

Reference yield:

N-(4-ethyl-2-hydroxy-phenyl)-acetamide (179542-88-2) → 4-amino-3-hydroxy(ethyl)benzene (182499-90-7)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; for 17h; Reflux;

upstream raw materials:

5-ethyl-2-nitrophenol

N-(4-ethyl-2-hydroxy-phenyl)-acetamide

3-ethylphenol

Downstream raw materials:

N-[2-Hydroxy-4-ethylphenyl]-N'-[2-bromophenyl] urea

Refernces

• 1、 Wakamatsu, Kazumasa,Tanaka, Hitomi,Tabuchi, Keisuke,Ojika, Makoto,Zucca, Fabio A.,Zecca, Luigi,Ito, Shosuke. "Reduction of the nitro group to amine by hydroiodic acid to synthesize o-aminophenol derivatives as putative degradative markers of neuromelanin". . p. 8039 - 8050. Retrieved 2014/07/08.
• 2、 -. "IL-8 RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.