3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Base Information

• Chemical Name: 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL
• CAS No.: 180635-74-9
• Molecular Formula: C10H11 F3 O
• Molecular Weight: 204.192
• Hs Code.: 2906299090
• Mol file: 180635-74-9.mol

Synonyms:3-(4-Trifluoromethylphenyl)-1-propanol;4-(Trifluoromethyl)benzenepropanol

Chemical Property of 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

Chemical Property:

• Vapor Pressure: 0.0143mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 246.6°C at 760 mmHg
• Flash Point: 108.1°C
• PSA: 20.23000
• Density: 1.202g/cm³
• LogP: 2.63030

Purity/Quality:

99% ^*data from raw suppliers

4-(Trifluoromethyl)benzenepropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Trifluoromethyl)benzenepropanol is used for asymmetric synthesis of tetrahydroisoquinolines by enzymic Pictet-Spengler reaction.

Technology Process of 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL

There total 16 articles about 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-tert-butylphenyl)propionic acid (1208-64-6) → 3‐(4‐(trifluoromethyl)phenyl)propan‐1‐ol (180635-74-9)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 20 - 70 ℃; for 16.5h; Cooling with ice;

Reference yield: 100.0%

3-(4-trifluoromethylphenyl)propionic acid (53473-36-2) → 3‐(4‐(trifluoromethyl)phenyl)propan‐1‐ol (180635-74-9)

Guidance literature:

3-(4-trifluoromethylphenyl)propionic acid; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 15.3h;

With methanol; In tetrahydrofuran; at 0 ℃;

Reference yield: 99.0%

→ 3‐(4‐(trifluoromethyl)phenyl)propan‐1‐ol (180635-74-9)

Guidance literature:

upstream raw materials:

methyl 3-(4-(trifluoromethyl)phenyl)propanoate

4-Trifluoromethylbenzaldehyde

methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate

3-(4-trifluoromethylphenyl)propionic acid

Downstream raw materials:

3-(4-trifluoromethylphenyl)propanal

Refernces

• 1、 Huang, Ling,Huang, Yi-You,Huang, Yue,Li, Jinjian,Li, Zhe,Luo, Hai-Bin,Su, Rui,Wu, Yinuo,Yuan, Han,Zhang, Chen,Zhou, Yan. "Design, synthesis, and evaluation of dihydropyranopyrazole derivatives as novel pde2 inhibitors for the treatment of alzheimer’s disease". . . Retrieved 2021/06/03.
• 2、 Wanat, Weronika,Talma, Micha?,Dziuk, B?a?ej,Kafarski, Pawe?. "Synthesis and inhibitory studies of phosphonic acid analogues of homophenylalanine and phenylalanine towards alanyl aminopeptidases". . p. 1 - 22. Retrieved 2020/09/18.