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CAS No.: | 180635-74-9 |
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Name: | 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL |
Article Data: | 29 |
Molecular Structure: | |
Formula: | C10H11 F3 O |
Molecular Weight: | 204.192 |
Synonyms: | 3-(4-Trifluoromethylphenyl)-1-propanol;4-(Trifluoromethyl)benzenepropanol |
Density: | 1.202g/cm3 |
Boiling Point: | 246.6°C at 760 mmHg |
Flash Point: | 108.1°C |
PSA: | 20.23000 |
LogP: | 2.63030 |
3-(4-trifluoromethylphenyl)propionic acid
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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Stage #1: 3-(4-trifluoromethylphenyl)propionic acid With borane-THF In tetrahydrofuran at 0 - 20℃; for 15.3h; Stage #2: With methanol In tetrahydrofuran at 0℃; | 100% |
With borane-THF In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere; | 100% |
With sodium tetrahydroborate; iodine In tetrahydrofuran at 70℃; for 16h; Cooling with ice; | 100% |
3-(4-tert-butylphenyl)propionic acid
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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With sodium tetrahydroborate; iodine In tetrahydrofuran at 20 - 70℃; for 16.5h; Cooling with ice; | 100% |
4-Iodobenzotrifluoride
allyl alcohol
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tetramethylammonium formiate; triphenylphosphine In water; N,N-dimethyl-formamide at 80℃; for 4h; Heck Reaction; regioselective reaction; | 67% |
4-(trifluoromethyl)benzylic alcohol
ethanol
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium tert-butylate In tetrahydrofuran at 100℃; for 24h; Inert atmosphere; | 37% |
methyl 3-(4-(trifluoromethyl)phenyl)propanoate
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Heating; | |
With lithium aluminium tetrahydride In diethyl ether at 0℃; | |
With sodium tetrahydroborate In tetrahydrofuran; methanol Reflux; |
4-Trifluoromethylbenzaldehyde
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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Multi-step reaction with 3 steps 1: tetrahydrofuran / Heating 2: H2 / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr 3: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme |
methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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Multi-step reaction with 2 steps 1: H2 / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr 2: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme |
4-Iodobenzotrifluoride
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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Multi-step reaction with 2 steps 1: palladium diacetate; lithium chloride; tetrabutylammomium bromide; lithium acetate dihydrate / N,N-dimethyl-formamide / 48 h / 20 °C 2: sodium tetrahydroborate / methanol / 0.17 h / 20 °C View Scheme |
3-(4-trifluoromethylphenyl)propanal
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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With sodium tetrahydroborate In methanol at 20℃; for 0.166667h; | 253 mg |
3-(4-trifluoromethylphenyl)prop-2-yn-1-ol
A
(Z)-3-(4-(trifluoromethyl)phenyl)-2-propene-1-ol
B
3-(4-trifluoromethylphenyl)-2-propen-1-ol
C
3-(4-(trifluoromethyl)phenyl)propan-1-ol
Conditions | Yield |
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With sodium tetrahydroborate; hydrogen; cobalt(II) diacetate tetrahydrate; ethylenediamine In tetrahydrofuran; ethanol; water at 20℃; under 2250.23 Torr; for 12h; Autoclave; Glovebox; diastereoselective reaction; | A n/a B n/a C n/a |