(R,S)-cyano(3-phenoxyphenyl)methyl butyrate

Base Information

• Chemical Name: (R,S)-cyano(3-phenoxyphenyl)methyl butyrate
• CAS No.: 120838-94-0
• Molecular Formula: C₁₈H₁₇NO₃
• Molecular Weight: 295.338
• Mol file: 120838-94-0.mol

Synonyms:(R,S)-cyano(3-phenoxyphenyl)methyl butyrate

Chemical Property of (R,S)-cyano(3-phenoxyphenyl)methyl butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-cyano(3-phenoxyphenyl)methyl butyrate

There total 1 articles about (R,S)-cyano(3-phenoxyphenyl)methyl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-hydroxy-2-(3-phenoxyphenyl)acetonitrile (39515-47-4) + butyryl chloride (141-75-3) → (R,S)-cyano(3-phenoxyphenyl)methyl butyrate (120838-94-0)

Guidance literature:

With pyridine; propan-1-ol; dmap; In toluene; at 20 ℃; for 14h;

DOI:10.1002/1099-0690(200205)2002:9<1516::AID-EJOC1516>3.0.CO;2-C

Reference yield: 85.0%

(R,S)-cyano(3-phenoxyphenyl)methyl butyrate (120838-94-0) → (S)-m-phenoxybenzaldehyde cyanohydrin (39515-47-4,52315-06-7,61826-76-4,71962-66-8) + (R)-cyano(3-phenoxyphenyl)methyl butanoate

Guidance literature:

With Pseudomonas cepacia lipase immobilised in a gelatin matrix; butan-1-ol; In hexane; for 8h;

DOI:10.1016/S0957-4166(00)00303-7

Reference yield: 70.0%

(R,S)-cyano(3-phenoxyphenyl)methyl butyrate (120838-94-0) → (R)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile (71962-66-8) + (S)-(+)-cyano(3-phenoxyphenyl)methyl butyrate (298702-31-5)

Guidance literature:

With Candida rugosa lipase; butan-1-ol; In hexane; at 25 ℃; for 8h; Enzymatic reaction;

DOI:10.1016/S0957-4166(01)00277-4

upstream raw materials:

2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

butyryl chloride

Downstream raw materials:

(S)-m-phenoxybenzaldehyde cyanohydrin

(R)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

(S)-(+)-cyano(3-phenoxyphenyl)methyl butyrate

Refernces