Multi-step reaction with 9 steps
1: sulfuric acid / 18 h / Reflux
2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 3 h / Reflux
3: ozone / methanol; dichloromethane / -78 °C
4: hydroxylamine hydrochloride / ethanol; water / 18 h / 45 °C
5: N-chloro-succinimide / N,N-dimethyl-formamide / 3.17 h / 20 °C
6: potassium hydrogencarbonate / ethyl acetate / 18 h / 20 °C
7: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C
8: 1,1'-carbonyldiimidazole / dichloromethane / 3 h
9: hydrogenchloride / tetrahydrofuran; methanol; water / 16 h / 40 °C
With
hydrogenchloride; N-chloro-succinimide; sulfuric acid; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium hydrogencarbonate; ozone; 1,1'-carbonyldiimidazole; lithium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;