Technology Process of 2-(2-ortho(2-bromoethyl)phenylpropyl)tetrahydropyran ether
There total 3 articles about 2-(2-ortho(2-bromoethyl)phenylpropyl)tetrahydropyran ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
diethyl ether;
at 0 - 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrahydrofuran / -5 - 20 °C / Inert atmosphere
2: triphenylphosphine hydrobromide / dichloromethane / 48 h / 0 °C / Reflux
3: trimethylbenzylammonium hydroxide / dimethyl sulfoxide; methanol / 60 - 65 °C
4: phosphorus tribromide / diethyl ether / 0 - 20 °C
With
trimethylbenzylammonium hydroxide; triphenylphosphine hydrobromide; phosphorus tribromide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine hydrobromide / dichloromethane / 48 h / 0 °C / Reflux
2: trimethylbenzylammonium hydroxide / dimethyl sulfoxide; methanol / 60 - 65 °C
3: phosphorus tribromide / diethyl ether / 0 - 20 °C
With
trimethylbenzylammonium hydroxide; triphenylphosphine hydrobromide; phosphorus tribromide;
In
methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;