5-BROMO-2-METHOXYBENZYLAMINE

Base Information

• Chemical Name: 5-BROMO-2-METHOXYBENZYLAMINE
• CAS No.: 166530-78-5
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.077
• Hs Code.: 2922299090
• Mol file: 166530-78-5.mol

Synonyms:5-BROMO-2-METHOXYBENZYLAMINE;(5-bromo-2-methoxyphenyl)methanamine;5-BROMO-2-METHOXYBENZYLAMIN;5-Bromo-2-methoxy-benzenemethanamine

Chemical Property of 5-BROMO-2-METHOXYBENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.00326mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 282.9 °C at 760 mmHg
• PKA: 8.86±0.10(Predicted)
• Flash Point: 124.9 °C
• PSA: 35.25000
• Density: 1.444 g/cm³
• LogP: 2.61670
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98.5% ^*data from raw suppliers

(5-bromo-2-methoxyphenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-METHOXYBENZYLAMINE

There total 5 articles about 5-BROMO-2-METHOXYBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-methoxybenzaldehyde (25016-01-7) → (5-bromo-2-methoxyphenyl)methanamine (166530-78-5)

Guidance literature:

5-bromo-2-methoxybenzaldehyde; With hydroxylamine hydrochloride; In ethanol; at 25 ℃; for 1h;

With hydrogenchloride; zinc; In ethanol; at 25 ℃; for 0.25h;

With ammonia; sodium hydroxide; In ethanol; at 25 ℃; for 0.25h;

DOI:10.1055/s-0035-1561346

Reference yield:

5-bromo-2-methoxybenzonitrile (144649-99-0) → (5-bromo-2-methoxyphenyl)methanamine (166530-78-5)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 70 ℃; for 16h; Sealed tube;

Reference yield:

C14H20BrN4O(1+)*Cl(1-) → (5-bromo-2-methoxyphenyl)methanamine (166530-78-5)

Guidance literature:

With hydrogenchloride; In water; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.9b01573

upstream raw materials:

5-bromo-2-methoxybenzaldehyde

4-bromo-2-(chloromethyl)-1-methoxybenzene

5-bromo-2-methoxy-benzyl alcohol

5-bromo-2-methoxybenzonitrile

Downstream raw materials:

N-(3-bromo-6-methoxy-benzyl)-2,2-diethoxy-acetamidine

t-Butyl N-(5-bromo-2-methoxybenzyl)carbamate

Refernces

• 1、 Cinelli, Maris A.,Reidl, Cory T.,Li, Huiying,Chreifi, Georges,Poulos, Thomas L.,Silverman, Richard B.. "First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate". . p. 4528 - 4554. Retrieved 2020/05/05.