2-(2,4,5-trifluorophenyl)-2-chloroacetic acid

Base Information

• Chemical Name: 2-(2,4,5-trifluorophenyl)-2-chloroacetic acid
• CAS No.: 1036273-14-9
• Molecular Formula: C₈H₄ClF₃O₂
• Molecular Weight: 224.567
• Mol file: 1036273-14-9.mol

Synonyms:2-(2,4,5-trifluorophenyl)-2-chloroacetic acid

Chemical Property of 2-(2,4,5-trifluorophenyl)-2-chloroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4,5-trifluorophenyl)-2-chloroacetic acid

There total 1 articles about 2-(2,4,5-trifluorophenyl)-2-chloroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4,5-trifluoromandelic acid (375369-29-2) → 2-(2,4,5-trifluorophenyl)-2-chloroacetic acid (1036273-14-9)

Guidance literature:

2,4,5-trifluoromandelic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 24h; Heating / reflux;

With sodium carbonate; In tert-butyl methyl ether; water;

With hydrogenchloride; In water; pH=2;

Reference yield: 83.0%

2-(2,4,5-trifluorophenyl)-2-chloroacetic acid (1036273-14-9) → (2,4,5-trifluorophenyl)acetic acid (209995-38-0)

Guidance literature:

2-(2,4,5-trifluorophenyl)-2-chloroacetic acid; With formic acid; triethylamine; palladium 10% on activated carbon; In water; at 80 ℃;

With hydrogenchloride; In water; Product distribution / selectivity;

upstream raw materials:

2,4,5-trifluoromandelic acid

Downstream raw materials:

(2,4,5-trifluorophenyl)acetic acid

Refernces