FMOC-DL-(PHENYL)GLY-OH

Base Information

• Chemical Name: FMOC-DL-(PHENYL)GLY-OH
• CAS No.: 163883-97-4
• Molecular Formula: C₂₃H₁₉NO₄
• Molecular Weight: 373.408
• Hs Code.: 2924299090
• Mol file: 163883-97-4.mol

Synonyms:FMOC-DL-PHG-OH;FMOC-DL-(PHENYL)GLY-OH;[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)]-PHENYL-ACETIC ACID;RARECHEM AK ML 0502;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-DL-PHENYLGLYCINE

Chemical Property of FMOC-DL-(PHENYL)GLY-OH

Chemical Property:

• PSA: 66.84000
• LogP: 4.65070

Purity/Quality:

98%min ^*data from raw suppliers

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylaceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-DL-(PHENYL)GLY-OH

There total 17 articles about FMOC-DL-(PHENYL)GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + L-α-phenylglycine (69-91-0,875-74-1,2835-06-5,2935-35-5) → N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine (102410-65-1,111524-95-9,163883-97-4)

Guidance literature:

Reference yield: 83.1%

(S)-2-phenylglycine (2935-35-5) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → Fmoc-Phg-OH (102410-65-1,163883-97-4)

Guidance literature:

(S)-2-phenylglycine; With sodium carbonate; In water; for 0.166667h; Cooling with ice;

(fluorenylmethoxy)carbonyl chloride; In 1,4-dioxane; water; for 12h;

DOI:10.1002/chem.202103071

Reference yield: 82.0%

(S)-2-phenylglycine (2935-35-5) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → Fmoc-Phg-OH (102410-65-1,163883-97-4)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 5 - 20 ℃;

DOI:10.1039/c9ob00014c

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

L-α-phenylglycine

H-D-Abu-Pro-OBu^t*TosOH

Pic(3-OBzl)-Thr(Fmoc-Phg-)-N₂H₃*2*HCl

Downstream raw materials:

H-Tyr-D-Orn<*>-Phg-Asp<*>-NH2

Refernces

• 1、 Einsiedler, Manuel,Jamieson, Cooper S.,Maskeri, Mark A.,Houk, Kendall N.,Gulder, Tobias A. M.. "Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones". supporting information. p. 8297 - 8302. Retrieved 2021/03/01.
• 2、 -. "IMMUNE CELL MODULATORS". Paragraph 00153-00154. . Retrieved 2021/08/27.