(2S)-2-(3-phenoxy-phenyl)-propan-1-ol

Base Information

• Chemical Name: (2S)-2-(3-phenoxy-phenyl)-propan-1-ol
• CAS No.: 1226783-62-5
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• Mol file: 1226783-62-5.mol

Synonyms:(2S)-2-(3-phenoxy-phenyl)-propan-1-ol

Chemical Property of (2S)-2-(3-phenoxy-phenyl)-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2-(3-phenoxy-phenyl)-propan-1-ol

There total 3 articles about (2S)-2-(3-phenoxy-phenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(3-phenoxy-phenyl)-propionaldehyde (59908-87-1) → (2S)-2-(3-phenoxy-phenyl)-propan-1-ol (1226783-62-5)

Guidance literature:

With Sulfolobus solfataricus alcohol dehydrogenase-10; NAD; In ethanol; at 80 ℃; for 12h; pH=9; optical yield given as %ee; enantioselective reaction; Inert atmosphere; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/ja910778p

Reference yield: 85.0%

carbon dioxide (124-38-9,18923-20-1) + 3-ethenylphenyl phenyl ether (63444-54-2) → (2S)-2-(3-phenoxy-phenyl)-propan-1-ol (1226783-62-5)

Guidance literature:

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; Triethoxysilane; cesium acetate; copper diacetate; In cyclohexane; at 60 ℃; for 24h; under 760.051 Torr; enantioselective reaction; Schlenk technique; Glovebox; Inert atmosphere;

DOI:10.1021/jacs.7b10149

Reference yield:

2-(3-phenoxy-phenyl)-propionaldehyde (59908-87-1) → (2S)-2-(3-phenoxy-phenyl)-propan-1-ol (1226783-62-5) + (2R)-2-(3-phenoxy-phenyl)-propan-1-ol

Guidance literature:

With ethanol; horse liver alcohol dehydrogenase; β-nicotinamide adenine dinucleotide, reduced dipotassium salt; for 24h; pH=8; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c005098a

upstream raw materials:

2-(3-phenoxy-phenyl)-propionaldehyde

carbon dioxide

3-ethenylphenyl phenyl ether

Downstream raw materials:

3'-phenoxyacetophenone

(S)-fenoprofen

Refernces

• 1、 Friest, Jacob A.,Maezato, Yukari,Broussy, Sylvain,Blum, Paul,Berkowitz, David B.. "Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (s)-profens". supporting information; experimental part. p. 5930 - 5931. Retrieved 2010/07/05.
• 2、 Galletti, Paola,Pori, Matteo,Giacomini, Daria. "One-step oxidation of 2-arylpropanols to 2-arylpropionic acids: Improving sustainability in the synthesis of profens". scheme or table. p. 2644 - 2648. Retrieved 2010/11/18.