2-(3-Phenoxyphenyl)propanal

Base Information

• Chemical Name: 2-(3-Phenoxyphenyl)propanal
• CAS No.: 59908-87-1
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• DSSTox Substance ID: DTXSID40552311
• Nikkaji Number: J247.521I
• Mol file: 59908-87-1.mol

Synonyms:2-(3-PHENOXYPHENYL)PROPANAL;59908-87-1;A-METHYL-3-PHENOXYBENZENEACETALDEHYDE;ALPHA-METHYL-3-PHENOXYBENZENEACETALDEHYDE;SCHEMBL4548753;DTXSID40552311;EN300-1869180;A832537

Chemical Property of 2-(3-Phenoxyphenyl)propanal

Chemical Property:

• PSA: 26.30000
• LogP: 3.78130
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 233

Purity/Quality:

98%min ^*data from raw suppliers

Ammethyl-3-phenoxybenzeneacetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C=O)C1=CC(=CC=C1)OC2=CC=CC=C2

Technology Process of 2-(3-Phenoxyphenyl)propanal

There total 8 articles about 2-(3-Phenoxyphenyl)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(3-phenoxy-phenyl)-propan-1-ol (32929-75-2) → 2-(3-phenoxy-phenyl)-propionaldehyde (59908-87-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; Inert atmosphere;

DOI:10.1021/ja910778p

Reference yield: 75.0%

tert-butyl 2-(3-phenoxyphenyl)propanoate → 2-(3-phenoxy-phenyl)-propionaldehyde (59908-87-1)

Guidance literature:

tert-butyl 2-(3-phenoxyphenyl)propanoate; With lithium diisobutyl-tert-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ja910778p

Reference yield: 10.0%

2-(3-phenoxy-phenyl)-propan-1-ol (32929-75-2) → 2-(3-phenoxy-phenyl)-propionaldehyde (59908-87-1) + Fenoprofen (29679-58-1,31879-05-7,32953-79-0)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen; In water; acetone; at 20 ℃; for 168h; Enzymatic reaction;

DOI:10.1002/cssc.201402136

upstream raw materials:

carbon monoxide

3-ethenylphenyl phenyl ether

2-(3-phenoxy-phenyl)-propan-1-ol

Fenoprofen

Downstream raw materials:

(2S)-2-(3-phenoxy-phenyl)-propan-1-ol

(R)-fenoprofen

Refernces

• 1、 Friest, Jacob A.,Maezato, Yukari,Broussy, Sylvain,Blum, Paul,Berkowitz, David B.. "Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (s)-profens". supporting information; experimental part. p. 5930 - 5931. Retrieved 2010/07/05.
• 2、 Neibecker, Denis,Reau, Regis,Lecolier, Serge. "Synthesis of 2-Arylpropionaldehydes through Hydroformylation". . p. 5208 - 5210. Retrieved 2007/10/02.