1-(6-(1-Hydroxy-ethyl)-pyridin-2-YL)-ethanol

Base Information

• Chemical Name: 1-(6-(1-Hydroxy-ethyl)-pyridin-2-YL)-ethanol
• CAS No.: 143329-89-9
• Molecular Formula: C9H13 N O2
• Molecular Weight: 167.208
• European Community (EC) Number: 683-463-7
• DSSTox Substance ID: DTXSID10402399
• Nikkaji Number: J1.179.079H
• Mol file: 143329-89-9.mol

Synonyms:143329-89-9;1,1'-(Pyridine-2,6-diyl)diethanol;1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL;1-[6-(1-hydroxyethyl)pyridin-2-yl]ethanol;(1S)-1-[6-[(1S)-1-Hydroxyethyl]pyridin-2-yl]ethanol;2,6-Pyridinedimethanol,a2,a6-dimethyl-;SCHEMBL4273303;DTXSID10402399;AKOS015909135;1,1'-(Pyridine-2,6-diyl)di(ethan-1-ol);alpha,alpha'-Dimethyl-2,6-pyridinedimethanol;1-(6-(1-hydroxyethyl)-(pyridin-2-yl))ethanol

Chemical Property of 1-(6-(1-Hydroxy-ethyl)-pyridin-2-YL)-ethanol

Chemical Property:

• PSA: 53.35000
• LogP: 1.18820
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

a2,a6-dimethyl-2,6-Pyridinedimethanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=NC(=CC=C1)C(C)O)O

Technology Process of 1-(6-(1-Hydroxy-ethyl)-pyridin-2-YL)-ethanol

There total 1 articles about 1-(6-(1-Hydroxy-ethyl)-pyridin-2-YL)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-Diacetylpyridine (1129-30-2) → α,α'-dihydroxy-1,3-diethylpyridine (143329-89-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 18h;

DOI:10.1021/ol035515k

Reference yield: 64.0%

α,α'-dihydroxy-1,3-diethylpyridine (143329-89-9) → 2,6-diethylpyridine (935-28-4)

Guidance literature:

With formic acid; zinc; for 24h; Heating;

Reference yield:

α,α'-dihydroxy-1,3-diethylpyridine (143329-89-9) → 2,6-Diacetylpyridine (1129-30-2)

Guidance literature:

With sodium hypochlorite; potassium dihydrogenphosphate; 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl; In acetonitrile; at 20 ℃; for 1.5h; pH=7.9;

DOI:10.1002/ejoc.201800569

upstream raw materials:

2,6-Diacetylpyridine

Downstream raw materials:

2,6-diethylpyridine

2-((R)-1-hydroxyethyl)-6-{(S)-1-[(R)-1-phenylethyl]aminoethyl}pyridine

2-((R)-1-hydroxyethyl)-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

2-((R)-1-acetoxyethyl)-6-{(R)-1-[(R)-1-phenylethyl]aminoethyl}pyridine

Refernces

• 1、 Uenishi, Jun'ichi,Aburatani, Sachiko,Takami, Taro. "Stereocomplexity and stereoselective synthesis of triamine molecules bearing four chiral carbon centers: Stereodifferentiated preparation of all 10 stereoisomers of 2,6-bis[1-(1-phenylethylamino)ethyl]pyridines". . p. 132 - 138. Retrieved 2007/10/03.
• 2、 Panosyan, Francis B.,Chin, Jik. "Autocatalytic Asymmetric Reduction of 2,6-Diacetylpyridine". . p. 3947 - 3949. Retrieved 2007/10/03.