5,7-dioxa-1-aza-6-phosphabicyclo[4.4.0]decane

Base Information

• Chemical Name: 5,7-dioxa-1-aza-6-phosphabicyclo[4.4.0]decane
• CAS No.: 74378-80-6
• Molecular Formula: C6H12 N O2 P
• Molecular Weight: 161.141
• Mol file: 74378-80-6.mol

Synonyms:NSC 316445

Chemical Property of 5,7-dioxa-1-aza-6-phosphabicyclo[4.4.0]decane

Chemical Property:

• Vapor Pressure: 15.6mmHg at 25°C
• Boiling Point: 119.9°C at 760 mmHg
• Flash Point: 26.3°C
• PSA: 35.29000
• LogP: 1.29380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-dioxa-1-aza-6-phosphabicyclo[4.4.0]decane

There total 2 articles about 5,7-dioxa-1-aza-6-phosphabicyclo[4.4.0]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

bis-(3-hydroxypropyl)amine (14002-33-6) → 2,10-dioxa-6-aza-1-phosphabicyclo<4.4.0>decane (74378-80-6)

Guidance literature:

With Hexamethylphosphorous triamide; In toluene; for 48h; Heating;

DOI:10.1021/ja00535a043

Reference yield:

methylimine-N,N-dipropionate methyl ester (3518-85-2) → 2,10-dioxa-6-aza-1-phosphabicyclo<4.4.0>decane (74378-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / LiAlH₄ / diethyl ether / 1.) room temperature, 1 h, 2.) reflux, 24 h

2: 16 percent / hexamethylphosphorous triamide / toluene / 48 h / Heating

With lithium aluminium tetrahydride; Hexamethylphosphorous triamide; In diethyl ether; toluene;

DOI:10.1021/ja00535a043

Reference yield:

methoxy-phenyl-sulfane (28715-70-0) + 2,10-dioxa-6-aza-1-phosphabicyclo<4.4.0>decane (74378-80-6) → 8a,8a-Dimethoxy-tetrahydro-1,8-dioxa-4a-aza-8aλ5-phospha-naphthalene (74378-83-9) + diphenyldisulfane (882-33-7)

Guidance literature:

In chloroform-d1; -20 deg C -> room temperature;

DOI:10.1021/ja00535a043

upstream raw materials:

bis-(3-hydroxypropyl)amine

methylimine-N,N-dipropionate methyl ester

Downstream raw materials:

8a,8a-Dimethoxy-tetrahydro-1,8-dioxa-4a-aza-8aλ⁵-phospha-naphthalene

diphenyldisulfane

2-Phenylsulfanyl-3-(3-phenylsulfanyl-propyl)-[1,3,2]oxazaphosphinane 2-oxide