2-Morpholinothiazole

Base Information

• Chemical Name: 2-Morpholinothiazole
• CAS No.: 21429-06-1
• Molecular Formula: C₇H₁₀N₂OS
• Molecular Weight: 170.235
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID40573122
• Nikkaji Number: J1.467.178A
• Wikidata: Q72493055
• Mol file: 21429-06-1.mol

Synonyms:2-Morpholinothiazole;21429-06-1;4-(Thiazol-2-yl)morpholine;4-(1,3-thiazol-2-yl)morpholine;4-Thiazol-2-yl-morpholine;2-(4-morpholinyl)thiazole;SCHEMBL1932306;DTXSID40573122;QHSGLIXDBAERBR-UHFFFAOYSA-N;WAA42906;MFCD08052659;AKOS002669600;AM86758;BS-25433;CS-0205183;N10098

Chemical Property of 2-Morpholinothiazole

Chemical Property:

• Melting Point: 46℃
• Boiling Point: 291℃
• Flash Point: 130℃
• Density: 1.256
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 170.05138412
• Heavy Atom Count: 11
• Complexity: 128

Purity/Quality:

≥95% ^*data from raw suppliers

4-Thiazol-2-ylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=NC=CS2

Technology Process of 2-Morpholinothiazole

There total 7 articles about 2-Morpholinothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 2-bromo-1,3-thiazole (3034-53-5,215777-74-5) → 2-(morpholine-1-yl)thiazole (21429-06-1)

Guidance literature:

at 120 ℃; for 9h;

Reference yield: 97.0%

morpholinothiourea (14294-10-1) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-(morpholine-1-yl)thiazole (21429-06-1)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; water; at 90 ℃; for 24h;

DOI:10.1039/c2sc21681g

Reference yield: 95.0%

1,3-thiazole (288-47-1) + 4-(benzoyloxy)morpholine (5765-65-1) → 2-(morpholine-1-yl)thiazole (21429-06-1)

Guidance literature:

1,3-thiazole; With bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; In tetrahydrofuran; toluene; at 20 ℃; for 1h; Inert atmosphere;

4-(benzoyloxy)morpholine; With copper diacetate; In tetrahydrofuran; toluene; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201311029

upstream raw materials:

morpholine

2-chlorothiazole

2-bromo-1,3-thiazole

morpholinothiourea

Downstream raw materials:

N-[4-(3-bromophenyl)-3-cyano-6-(2-morpholin-4-yl-1,3-thiazol-5-yl)pyridin-2-yl]formamidine

2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-1,3-thiazol-5-yl]nicotinonitrile

2-(morpholin-4-yl)thiazole-5-carbaldehyde

Refernces

• 1、 Boga, Carla,Bordoni, Silvia,Calvaresi, Matteo,Chugunova, Elena,Iannuzzo, Leonardo,Micheletti, Gabriele,Telese, Dario. "Intriguing enigma of nitrobenzofuroxan's ‘Sphinx’: Boulton-Katritzky rearrangement or unusual evidence of theN-1/N-3-oxide rearrangement?". . p. 34670 - 34680. Retrieved 2020.
• 2、 Dutta, Pratip Kumar,Sen, Subhabrata,Saha, Debasree,Dhar, Basabbijayi. "Solid Supported Nano Structured Cu-Catalyst for Solvent/Ligand Free C2 Amination of Azoles". supporting information. p. 657 - 665. Retrieved 2018/02/14.