C₅₄H₅₂ClN₄O₁₅P

Base Information

• Chemical Name: C₅₄H₅₂ClN₄O₁₅P
• CAS No.: 81187-04-4
• Molecular Formula: C₅₄H₅₂ClN₄O₁₅P
• Molecular Weight: 1063.45
• Mol file: 81187-04-4.mol

Synonyms:C₅₄H₅₂ClN₄O₁₅P

Chemical Property of C₅₄H₅₂ClN₄O₁₅P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₅₂ClN₄O₁₅P

There total 11 articles about C₅₄H₅₂ClN₄O₁₅P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

<(MeO)2Tr>TdΦ(1-) + 3'-O-benzoylthymidine (17331-53-2) → C54H52ClN4O15P (81187-04-4)

Guidance literature:

With TPSPy; In pyridine; for 0.5h;

DOI:10.1016/S0040-4039(01)93020-5

Reference yield: 88.0%

2-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate (81196-20-5) + 3'-O-benzoylthymidine (17331-53-2) → C54H52ClN4O15P (81187-04-4)

Guidance literature:

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; In pyridine; at 20 ℃; for 3h;

DOI:10.1002/hlca.19820650803

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → C54H52ClN4O15P (81187-04-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 1 h / 20 °C

2: benzenesulfonic acid / CHCl₃; methanol / 0.17 h / 0 °C

3: 88 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3 h / 20 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; benzenesulfonic acid; In pyridine; methanol; chloroform;

DOI:10.1002/hlca.19820650803

upstream raw materials:

2-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate

3'-O-benzoylthymidine

4,4'-dimethoxytrityl chloride

5'-O-(dimethoxytrityl)thymidine 3'-(o-chlorophenyl β-cyanoethyl phosphate)

Downstream raw materials:

C₃₃H₃₄ClN₄O₁₃P

Refernces

• 1、 Ohtsuka, E.,Tozuka, Z.,Ikehara, M.. "NEW CONDENSING REAGENTS FOR STEREOSPECIFIC SYNTHESIS OF DINUCLEOSIDE MONOPHOSPHATE ARYL ESTERS". . p. 4483 - 4486. Retrieved 2007/10/02.