(+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone

Base Information

• Chemical Name: (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone
• CAS No.: 1383253-86-8
• Molecular Formula: C₂₃H₁₈ClF₃O₂
• Molecular Weight: 418.843
• Mol file: 1383253-86-8.mol

Synonyms:(+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone

Chemical Property of (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone

There total 5 articles about (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid (95233-37-7,49708-81-8,1346600-43-8) + 2-(trifluoromethyl)naphthalene-1,4-dione (313-10-0) → (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone (1383253-86-8)

Guidance literature:

With ammonium persulfate; silver nitrate; In water; acetonitrile; at 85 ℃; for 2.75h;

DOI:10.1039/c2ob25229e

Reference yield:

1,4-dimethoxy-2-(trifluoromethyl)naphthalene (1383253-88-0) → (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone (1383253-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.33 h / 20 °C

2: ammonium persulfate; silver nitrate / water; acetonitrile / 2.75 h / 85 °C

With ammonium persulfate; ammonium cerium (IV) nitrate; silver nitrate; In water; acetonitrile;

DOI:10.1039/c2ob25229e

Reference yield:

1,4-dimethoxynaphthalene (10075-62-4) → (+/-)-trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-trifluoromethyl[1,4]naphthoquinone (1383253-86-8)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine / chloroform / 0.75 h / 0 °C

2: N,N-dimethyl acetamide; toluene / 145 °C / Inert atmosphere

3: ammonium cerium (IV) nitrate / water; acetonitrile / 0.33 h / 20 °C

4: ammonium persulfate; silver nitrate / water; acetonitrile / 2.75 h / 85 °C

With ammonium persulfate; ammonium cerium (IV) nitrate; bromine; silver nitrate; In chloroform; N,N-dimethyl acetamide; water; toluene; acetonitrile;

DOI:10.1039/c2ob25229e

upstream raw materials:

1,4-dimethoxy-2-(trifluoromethyl)naphthalene

1,4-dimethoxynaphthalene

(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

2-(trifluoromethyl)naphthalene-1,4-dione

Refernces