7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide

Base Information

• Chemical Name: 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide
• CAS No.: 866037-63-0
• Molecular Formula: C₃₈H₅₂N₄O₆
• Molecular Weight: 660.854
• Mol file: 866037-63-0.mol

Synonyms:7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide

Chemical Property of 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide

There total 4 articles about 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate (866037-62-9) → 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide (866037-63-0)

Guidance literature:

With hydrazine hydrate; In methanol; at 50 ℃; for 12h;

DOI:10.1021/jo050913h

Reference yield:

methyl 3-O-acetyl-7,12-di-O-phenylaminocarbonyl-cholate (866037-61-8) → 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide (866037-63-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 1 h / Heating

2: 185 mg / potassium carbonate / dimethylformamide / 15 h / 70 °C

3: 87 percent / hydrazine monohydrate / methanol / 12 h / 50 °C

With sodium hydroxide; potassium carbonate; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo050913h

Reference yield:

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-7,12-bis-phenylcarbamoyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid → 7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide (866037-63-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 185 mg / potassium carbonate / dimethylformamide / 15 h / 70 °C

2: 87 percent / hydrazine monohydrate / methanol / 12 h / 50 °C

With potassium carbonate; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo050913h

upstream raw materials:

methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate

methyl 3-O-acetyl-7,12-di-O-phenylaminocarbonyl-cholate

methyl cholate 3-acetate

Refernces