methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate

Base Information

• Chemical Name: methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate
• CAS No.: 866037-62-9
• Molecular Formula: C₄₁H₅₄N₂O₉
• Molecular Weight: 718.888
• Mol file: 866037-62-9.mol

Synonyms:methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate

Chemical Property of methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate

There total 3 articles about methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-7,12-bis-phenylcarbamoyloxy-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid + bromoacetic acid methyl ester (96-32-2) → methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate (866037-62-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 15h;

DOI:10.1021/jo050913h

Reference yield:

methyl 3-O-acetyl-7,12-di-O-phenylaminocarbonyl-cholate (866037-61-8) → methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate (866037-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 1 h / Heating

2: 185 mg / potassium carbonate / dimethylformamide / 15 h / 70 °C

With sodium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo050913h

Reference yield:

methyl cholate 3-acetate (7443-91-6) → methoxycarbonylmethyl 7,12-di-O-phenylaminocarbonyl-cholate (866037-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / trimethylsilyl chloride / CH₂Cl₂ / 20 °C

2: sodium hydroxide / methanol / 1 h / Heating

3: 185 mg / potassium carbonate / dimethylformamide / 15 h / 70 °C

With sodium hydroxide; chloro-trimethyl-silane; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050913h

upstream raw materials:

bromoacetic acid methyl ester

methyl 3-O-acetyl-7,12-di-O-phenylaminocarbonyl-cholate

methyl cholate 3-acetate

Downstream raw materials:

7,12-di-O-phenylaminocarbonyl-cholic acid hydrazide

Refernces