16α-bromo-5α-androstane-3,17-dione

Base Information

• Chemical Name: 16α-bromo-5α-androstane-3,17-dione
• CAS No.: 94441-01-7
• Molecular Formula: C₁₉H₂₇BrO₂
• Molecular Weight: 367.326
• Mol file: 94441-01-7.mol

Synonyms:16α-bromo-5α-androstane-3,17-dione

Chemical Property of 16α-bromo-5α-androstane-3,17-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16α-bromo-5α-androstane-3,17-dione

There total 1 articles about 16α-bromo-5α-androstane-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

16α-bromo-3β-hydroxy-5α-androstan-17-one (28507-02-0) → 16α-bromo-5α-androstane-3,17-dione (94441-01-7)

Guidance literature:

With Jones reagent; In acetone; for 1h; Cooling with ice;

Reference yield:

16α-bromo-5α-androstane-3,17-dione (94441-01-7) → 16β-(1H-1,2,4-triazol-1-yl)-3β-(N-methylphenylamino)-5α-androstan-17-one (1332954-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 24 h / 80 °C

2: sodium cyanoborohydride; acetic acid / methanol / 24 h / 40 °C / pH Ca_. 6

With sodium cyanoborohydride; acetic acid; In methanol; acetonitrile;

DOI:10.1016/j.ejmech.2011.05.030

Reference yield:

16α-bromo-5α-androstane-3,17-dione (94441-01-7) → 16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17-one (1334215-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 24 h / 80 °C

2: sodium cyanoborohydride; acetic acid / methanol / 24 h / 40 °C / pH Ca_. 6

With sodium cyanoborohydride; acetic acid; In methanol; acetonitrile;

DOI:10.1016/j.ejmech.2011.05.030

upstream raw materials:

16α-bromo-3β-hydroxy-5α-androstan-17-one

Downstream raw materials:

16β-(1H-1,2,4-triazol-1-yl)-3β-(N-methylphenylamino)-5α-androstan-17-one

16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17-one

16β-(1H-1,2,3-triazol-1-yl)-3β-(N-methylphenylamino)-5α-androstan-17-one

16β-(1H-1,2,3-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17-one

Refernces

• 1、 Guo, Hao,Zhang, Guolan,Zhang, Tao,He, Xianran,Wu, Zhongyuan,Xiao, Yuling,Pan, Yuanhu,Qiu, Guofu,Liu, Peng,Hu, Xianming. "Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents". experimental part. p. 3662 - 3674. Retrieved 2011/11/05.