(3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide

Base Information

• Chemical Name: (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
• CAS No.: 328273-17-2
• Molecular Formula: C₂₀H₃₆N₄O₄S
• Molecular Weight: 428.596
• Mol file: 328273-17-2.mol

Synonyms:(3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide

Chemical Property of (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide

There total 1 articles about (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) + biotin (58-85-5,22879-79-4) → (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide (328273-17-2)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield: 100.0%

(3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide (328273-17-2) → N-(5-aminopentyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)pentanamide (115416-38-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield: 79.0%

2,6-difluoro-4-(4,4,5,5-tetraphenyl-1,3,2-bioxaborolan-2-yl)benzoic acid (1031857-97-2) + (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide (328273-17-2) → C48H49BF2N4O5S (1031858-01-1)

Guidance literature:

(3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

2,6-difluoro-4-(4,4,5,5-tetraphenyl-1,3,2-bioxaborolan-2-yl)benzoic acid; With pyridine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 16h; Further stages.;

DOI:10.1016/j.tetlet.2008.03.021

upstream raw materials:

5-tert-butoxycarbonylamino-1-aminopentane

biotin

Downstream raw materials:

N-(5-aminopentyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)pentanamide

C₂₂H₃₀F₂N₄O₃S

C₂₈H₄₁BF₂N₄O₅S

C₄₈H₄₉BF₂N₄O₅S

Refernces

• 1、 -. "BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF". Paragraph 00181. . Retrieved 2021/08/14.
• 2、 Gao, Feng,Liang, Yuru,Zhou, Pengfei,Cheng, Jiayi,Ding, Kuiling,Wang, Yang. "Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin". . p. 177 - 194. Retrieved 2019/06/13.