5-Pyrimidinol, 2-(methylthio)- (6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: 5-Pyrimidinol, 2-(methylthio)- (6CI,7CI,8CI,9CI)
• CAS No.: 4874-33-3
• Molecular Formula: C5H6N2OS
• Molecular Weight: 142.181
• Hs Code.: 2933599090
• Mol file: 4874-33-3.mol

Synonyms:2-(Methylmercapto)-5-hydroxypyrimidine;2-(Methylthio)-5-hydroxypyrimidine;2-(Methylthio)-5-pyrimidinol;2-Methylsulfanylpyrimidin-5-ol;

Chemical Property of 5-Pyrimidinol, 2-(methylthio)- (6CI,7CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.000597mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 301.2 °C at 760 mmHg
• Flash Point: 136 °C
• PSA: 71.31000
• Density: 1.37 g/cm³
• LogP: 0.90410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Methylthio)pyrimidin-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinol, 2-(methylthio)- (6CI,7CI,8CI,9CI)

There total 4 articles about 5-Pyrimidinol, 2-(methylthio)- (6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-methylthio-5-dimethylaminomethyleneaminopyrimidine (52767-93-8) → 2-methylthio-5-hydroxypyrimidine (4874-33-3)

Guidance literature:

With sulfuric acid; for 1h; Heating;

DOI:10.1007/BF00756420

Reference yield: 48.0%

5-bromo-2-methylthiopyrimidine (14001-67-3) → 2-methylthio-5-hydroxypyrimidine (4874-33-3)

Guidance literature:

5-bromo-2-methylthiopyrimidine; With potassium acetate; bis(pinacol)diborane; palladium diacetate; In N,N-dimethyl-formamide;

With sodium perborate; In tetrahydrofuran; water;

DOI:10.1016/j.tetlet.2006.08.018

Reference yield:

2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (940284-18-4) → 2-methylthio-5-hydroxypyrimidine (4874-33-3)

Guidance literature:

With sodium peroxoborate tetrahydrate; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

upstream raw materials:

2-methylthio-5-dimethylaminomethyleneaminopyrimidine

5-bromo-2-methylthiopyrimidine

2-(methylsulfanyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

Downstream raw materials:

5-fluoro-2-(methylthio)pyrimidine

tert-butyl (4-(benzylsulfonyl)-6-fluoro-2-((2-(methylsulfonyl)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

C₂₅H₂₆N₂O₅S

Refernces

• 1、 -. "PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS". Page/Page column 110. . Retrieved 2010/04/03.