1H-Pyrrolizine,2,3-dihydro-1-methyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolizine,2,3-dihydro-1-methyl-(9CI)
• CAS No.: 49836-37-5
• Molecular Formula: C₈H₁₁N
• Molecular Weight: 121.182
• Mol file: 49836-37-5.mol

Synonyms:1H-Pyrrolizine,2,3-dihydro-1-methyl-(9CI)

Chemical Property of 1H-Pyrrolizine,2,3-dihydro-1-methyl-(9CI)

Chemical Property:

• Boiling Point: 75 - 80 °C (19 mmHg)
• PSA: 4.93000
• LogP: 1.99530

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrolizine,2,3-dihydro-1-methyl-(9CI)

There total 4 articles about 1H-Pyrrolizine,2,3-dihydro-1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N'-(4-(1H-pyrrol-1-yl)butan-2-ylidene)-4-methylbenzenesulfonohydrazide → 1-methyl-2,3-dihydro-1H-pyrrolizine (49836-37-5)

Guidance literature:

With 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)porphyrin cobalt(II); potassium carbonate; In 1,4-dioxane; at 105 ℃; for 10h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201506418

Reference yield:

1,2-dihydro-1-pyrrolizinone (17266-64-7) + Methyltriphenylphosphonium bromide (1779-49-3) + Methylenetriphenylphosphorane (19493-09-5) → 1-methyl-2,3-dihydro-1H-pyrrolizine (49836-37-5)

Guidance literature:

palladium; In methanol; ice-water; dimethyl sulfoxide;

Reference yield:

(1-pyrrolidyl)butan-2-one → 1-methyl-2,3-dihydro-1H-pyrrolizine (49836-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)porphyrin cobalt(II) / methanol / 20 - 60 °C / Inert atmosphere; Schlenk technique

2: 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)porphyrin cobalt(II); potassium carbonate / 1,4-dioxane / 10 h / 105 °C / Inert atmosphere; Schlenk technique

With 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)porphyrin cobalt(II); potassium carbonate; In 1,4-dioxane; methanol;

DOI:10.1002/anie.201506418

upstream raw materials:

1,2-dihydro-1-pyrrolizinone

Methyltriphenylphosphonium bromide

Methylenetriphenylphosphorane

Refernces

• 1、 -. "5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents". . . Retrieved 2008/06/13.