methyl N-(2,6-dimethoxybenzoyl)glycine ester

Base Information

• Chemical Name: methyl N-(2,6-dimethoxybenzoyl)glycine ester
• CAS No.: 51579-20-5
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.255
• Mol file: 51579-20-5.mol

Synonyms:methyl N-(2,6-dimethoxybenzoyl)glycine ester

Chemical Property of methyl N-(2,6-dimethoxybenzoyl)glycine ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl N-(2,6-dimethoxybenzoyl)glycine ester

There total 2 articles about methyl N-(2,6-dimethoxybenzoyl)glycine ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-6-dimethoxybenzoic acid (1466-76-8) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl N-(2,6-dimethoxybenzoyl)glycine ester (51579-20-5)

Guidance literature:

With dmap; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 29h;

DOI:10.1080/00397919908086185

Reference yield:

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 2,6-dimethoxybenzoyl chloride (1989-53-3) → methyl N-(2,6-dimethoxybenzoyl)glycine ester (51579-20-5)

Guidance literature:

In dichloromethane;

DOI:10.1002/jhet.5570100609

Reference yield: 98.0%

methyl N-(2,6-dimethoxybenzoyl)glycine ester (51579-20-5) → 2-(2,6-dimethoxybenzamido)acetic acid (51579-21-6)

Guidance literature:

methyl N-(2,6-dimethoxybenzoyl)glycine ester; With lithium hydroxide; In tetrahydrofuran; water;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2012.04.018

upstream raw materials:

glycine ethyl ester hydrochloride

2,6-dimethoxybenzoyl chloride

2-6-dimethoxybenzoic acid

Downstream raw materials:

2-(2,6-dimethoxybenzamido)acetic acid

N-hydrazinocarbonylmethyl-2,6-dimethoxy-benzamide

2-(2,6-dimethoxy-phenyl)-4-ethoxymethylene-4H-oxazol-5-one

N-[2-(2,6-dimethoxy-phenyl)-5-oxo-oxazol-4-ylidenemethyl]-valine

Refernces

• 1、 Al-Afaleq,Abubshait. "L-amino acid esters studies: Part I: Synthesis of new methyl N- (dimethoxy/3,5-diacetoxybenzoyl)-L-amino acid ester derivatives". . p. 1965 - 1976. Retrieved 2007/10/03.