2-(4-chloromethyl-phenyl)-propionic acid ethyl ester

Base Information

• Chemical Name: 2-(4-chloromethyl-phenyl)-propionic acid ethyl ester
• CAS No.: 43153-03-3
• Molecular Formula: C12H15 Cl O2
• Molecular Weight: 226.703
• Hs Code.: 2916399090
• Mol file: 43153-03-3.mol

Synonyms:Ethyl2-[4-(chloromethyl)phenyl]propionate

Chemical Property of 2-(4-chloromethyl-phenyl)-propionic acid ethyl ester

Chemical Property:

• Boiling Point: 303.8±22.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.112±0.06 g/cm3(Predicted)
• LogP: 3.09200
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

4-(Chloromethyl)-α-methyl-benzeneaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-chloromethyl-phenyl)-propionic acid ethyl ester can be used in the preparation of Ibuprofen impurities and derivatives.

Technology Process of 2-(4-chloromethyl-phenyl)-propionic acid ethyl ester

There total 6 articles about 2-(4-chloromethyl-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 2--propionate (118618-33-0) → 2-(4-chloromethylphenyl)-propionic ethyl ester (43153-03-3)

Guidance literature:

With hydrogenchloride; for 0.5h; Ambient temperature;

Reference yield:

2-(4-amminofenil)propionico d'etile (32868-25-0) → 2-(4-chloromethylphenyl)-propionic ethyl ester (43153-03-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaNO₂; 2.) K₂CO₃; 3.) CuCN / 1.) 6M HCl, H₂O, 0-5 deg C, 15 min; 2.) 0-5 deg C; 3.) water, 110 deg C, 25 min

2: 57 percent / Raney-alloy / formic acid / 1 h / Heating

3: 88 percent / NaBH₄ / methanol; H₂O / 20 - 22 °C

4: 92 percent / 12M HCl / 0.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; Raney-alloy; potassium carbonate; sodium nitrite; In methanol; formic acid; water;

Reference yield:

ethyl 2-(4-formylphenyl)propionate (43153-04-4) → 2-(4-chloromethylphenyl)-propionic ethyl ester (43153-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaBH₄ / methanol; H₂O / 20 - 22 °C

2: 92 percent / 12M HCl / 0.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; In methanol; water;

upstream raw materials:

chloromethyl methyl ether

ethyl 2-phenylpropanoate

ethyl 2--propionate

2-(4-amminofenil)propionico d'etile

Downstream raw materials:

ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclohexan-1-ylmethyl)phenyl]propionate

ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclopentan-1-ylmethyl)phenyl]propionate

ethyl 2-(4-iodomethylphenyl)propionate

Ethyl 2-[4-(2,2-diethoxycarbonyl-3-methylbutyl)phenyl]propionate

Refernces

• 1、 Maillard,Langlois,Delaunay,Tri. "Antiinflammatory derivatives of phenylacetic acid; derivatives substituted by a heterocycle at the phenyl ring". . p. 487 - 494. Retrieved 2007/10/08.