3-DIMETHYLAMINOPHENYLMETHYLCARBINOL

Base Information

• Chemical Name: 3-DIMETHYLAMINOPHENYLMETHYLCARBINOL
• CAS No.: 5339-01-5
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• Mol file: 5339-01-5.mol

Synonyms:Benzylalcohol, m-(dimethylamino)-a-methyl- (8CI);1-[3-(Dimethylamino)phenyl]ethanol;NSC 3455;

Chemical Property of 3-DIMETHYLAMINOPHENYLMETHYLCARBINOL

Chemical Property:

• Refractive Index: 1.5600-1.5640
• Boiling Point: 280.5 °C at 760 mmHg
• Flash Point: 132.8 °C
• Density: 1.042 g/cm³

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-Dimethylaminophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-DIMETHYLAMINOPHENYLMETHYLCARBINOL

There total 3 articles about 3-DIMETHYLAMINOPHENYLMETHYLCARBINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(1-hydroxyethyl)aniline (2454-37-7) → 1-(3-(dimethylamino)phenyl)ethan-1-ol (5339-01-5)

Guidance literature:

formaldehyd; 3-(1-hydroxyethyl)aniline; With acetic acid; for 1h; Inert atmosphere;

With sodium cyanoborohydride; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.202001593

Reference yield:

1-(3-dimethylaminophenyl)-1-ethanone (18992-80-8) → 1-(3-(dimethylamino)phenyl)ethan-1-ol (5339-01-5)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201912605

Reference yield:

→ 1-(3-(dimethylamino)phenyl)ethan-1-ol (5339-01-5)

Guidance literature:

s. Ref. 3: Jensen, Ph. D. Thesis, Univ. of Washington, 1967;

DOI:10.1021/ja00757a040

upstream raw materials:

1-(3-dimethylaminophenyl)-1-ethanone

formaldehyd

3-(1-hydroxyethyl)aniline

Downstream raw materials:

1-(3-dimethylaminophenyl)-1-ethanone

(S)-1-(3-dimethylaminophenyl)ethan-1-ol

(R)-1-(3-(dimethylamino)phenyl)ethan-1-ol

(S)-1-(3-dimethylaminophenyl)ethyl propanoate

Refernces

• 1、 Passera, Alessandro,Mezzetti, Antonio. "RETRACTED ARTICLE: The Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege". supporting information. p. 187 - 191. Retrieved 2019/12/11.