9-Fluorenylmethyl N-p-chlorphenyl carbamate

Base Information

• Chemical Name: 9-Fluorenylmethyl N-p-chlorphenyl carbamate
• CAS No.: 68089-94-1
• Molecular Formula: C₂₁H₁₆ClNO₂
• Molecular Weight: 349.817
• Mol file: 68089-94-1.mol

Synonyms:9-Fluorenylmethyl N-p-chlorphenyl carbamate

Chemical Property of 9-Fluorenylmethyl N-p-chlorphenyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-Fluorenylmethyl N-p-chlorphenyl carbamate

There total 9 articles about 9-Fluorenylmethyl N-p-chlorphenyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 4-chloro-aniline (106-47-8) → 9-Fluorenylmethyl N-p-chlorphenyl carbamate (68089-94-1)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.0666667h; Sonication; Irradiation; Green chemistry;

DOI:10.5935/0103-5053.20150286

Reference yield: 90.0%

9-Fluorenylmethanol (24324-17-2) + p-chlorphenylisocyanate (104-12-1) → 9-Fluorenylmethyl N-p-chlorphenyl carbamate (68089-94-1)

Guidance literature:

With triethylamine; In benzene;

DOI:10.1021/jo00153a008

Reference yield: 75.3%

2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate (136453-58-2) → 9-Fluorenylmethyl N-p-chlorphenyl carbamate (68089-94-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo001150v

upstream raw materials:

9-Fluorenylmethanol

p-chlorphenylisocyanate

2,7-bis(trimethylsilyl)-9-fluorenylmethyl p-chlorocarbanilate

9,9'-bis(trimethylsilyl)fluorene

Downstream raw materials:

9-methylene-fluorene

4-chloro-aniline

p-chloroaniline hydrochloride

Refernces

• 1、 Carpino,Wu. "Solubilizing influence of 2,7-bis(trimethylsilyl) substitution on the Fmoc residue". . p. 9238 - 9240. Retrieved 2007/10/03.
• 2、 Carpino, Louis A.,Mansour, E. M. E.,Cheng, C. H.,Williams, James R.,MacDonald, Russell,et al.. "Polystyrene-Based Deblocking-Scavenging Agents for the 9-Fluorenylmethyloxycarbonyl Amino-Protecting Group". . p. 661 - 665. Retrieved 2007/10/02.