N-benzyl-4-nitrobenzamide

Base Information

• Chemical Name: N-benzyl-4-nitrobenzamide
• CAS No.: 2585-26-4
• Molecular Formula: C14H12 N2 O3
• Molecular Weight: 256.261
• Mol file: 2585-26-4.mol

Synonyms:Benzamide,N-benzyl-p-nitro- (6CI,7CI,8CI); 4-Nitro-N-(phenylmethyl)benzamide;N-(4-Nitrobenzoyl)benzylamine; N-Benzyl-4-nitrobenzamide;N-Benzyl-p-nitrobenzamide; NSC 405529

Chemical Property of N-benzyl-4-nitrobenzamide

Chemical Property:

• Vapor Pressure: 1.05E-09mmHg at 25°C
• Melting Point: 140-143 °C
• Boiling Point: 488.9°Cat760mmHg
• PKA: 13.50±0.46(Predicted)
• Flash Point: 249.5°C
• PSA: 74.92000
• Density: 1.266g/cm³
• LogP: 3.43890

Purity/Quality:

99% ^*data from raw suppliers

N-benzyl-4-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl-4-nitrobenzamide

There total 61 articles about N-benzyl-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzylamine (100-46-9) + 4-nitro-benzoic acid (62-23-7) → 4-nitro-N-benzylbenzamide (2585-26-4)

Guidance literature:

With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetlet.2008.02.001

Reference yield: 97.0%

4-nitro-benzoyl chloride (122-04-3) + benzylamine (100-46-9) → 4-nitro-N-benzylbenzamide (2585-26-4)

Guidance literature:

DOI:10.1071/CH15504

Reference yield: 96.0%

N-benzyl-4-nitrothiobenzamide (50903-08-7) → 4-nitro-N-benzylbenzamide (2585-26-4)

Guidance literature:

With dihydrogen peroxide; zirconium(IV) chloride; In ethanol; water; at 25 ℃; for 0.0833333h; chemoselective reaction;

DOI:10.1055/s-0028-1083314

upstream raw materials:

2-methyl-3-(4-nitrobenzoyl)-4H-chromen-4-one

benzylamine

4-nitro-benzoyl chloride

cyclohexane

Downstream raw materials:

benzaldehyde

4-nitrobenzamide

N-(phenylmethyl)acetamide

N-benzyl-2,2-dimethylpropanamide

Refernces

• 1、 Boyle, Mhairi,Livingstone, Keith,Henry, Martyn C.,Elwood, Jessica M. L.,Lopez-Fernandez, J. Daniel,Jamieson, Craig. "Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides". . p. 334 - 338. Retrieved 2022/01/20.
• 2、 Zubar, Viktoriia,Dewanji, Abhishek,Rueping, Magnus. "Chemoselective Hydrogenation of Nitroarenes Using an Air-Stable Base-Metal Catalyst". supporting information. p. 2742 - 2747. Retrieved 2021/05/05.