5-bromo-2,3-dihydro-1H-inden-2-amine hydrobromide

Base Information

• Chemical Name: 5-bromo-2,3-dihydro-1H-inden-2-amine hydrobromide
• CAS No.: 321352-52-7
• Molecular Formula: BrH*C₉H₁₀BrN
• Molecular Weight: 293.001
• Hs Code.: 2921499090
• DSSTox Substance ID: DTXSID20479855
• Mol file: 321352-52-7.mol

Synonyms:321352-52-7;5-bromo-2,3-dihydro-1H-inden-2-amine hydrobromide;5-Bromoindan-2-ylamine hydrobromide;2-Amino-5-bromoindane hydrobromide;5-BROMO-INDAN-2-YLAMINE HYDROBROMIDE;5-bromo-2,3-dihydro-1H-inden-2-amine;hydrobromide;5-BROMO-2,3-DIHYDRO-1H-INDEN-2-AMINE HBR;MFCD05663963;C9H11Br2N;1H-Inden-2-amine, 5-bromo-2,3-dihydro-, hydrobromide;SCHEMBL584993;AMY9095;DTXSID20479855;5-bromoindan-2-amine hydrobromide;WVNGAALXGMXZJI-UHFFFAOYSA-N;5-bromo-2-aminoindane hydrobromide;BCP05915;AKOS015902417;AB22071;CS-W003235;SY014687;(+/-)-5-bromo-2-aminoindan hydrobromide;(+/-)-5-bromo-2-aminoindane hydrobromide;FT-0688499;EN300-322129;A821168;5-bromanyl-2,3-dihydro-1H-inden-2-amine hydrobromide;(5-bromo-2,3-dihydro-1H-inden-2-yl)amine hydrobromide;Z1741978324;2-amino-5-bromo-2,3-dihydro-1H-indene hydrobromide salt;5-Bromo-2,3-dihydro-1H-inden-2-amine--hydrogen bromide (1/1)

Chemical Property of 5-bromo-2,3-dihydro-1H-inden-2-amine hydrobromide

Chemical Property:

• Vapor Pressure: 0.00469mmHg at 25°C
• Melting Point: >290℃ (methanol ethyl ether )
• Boiling Point: 276.8 °C at 760 mmHg
• Flash Point: 121.2 °C
• PSA: 26.02000
• LogP: 3.53340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 292.92378
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99.0% ^*data from raw suppliers

5-Bromo-2,3-dihydro-1H-inden-2-amineHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CC2=C1C=CC(=C2)Br)N.Br

Technology Process of 5-bromo-2,3-dihydro-1H-inden-2-amine hydrobromide

There total 5 articles about 5-bromo-2,3-dihydro-1H-inden-2-amine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-aminoindane hydrochloride (2338-18-3) → 5-bromo-2-aminoindane hydrobromide (321352-52-7)

Guidance literature:

2-aminoindane hydrochloride; With bromine; In water; at 20 - 60 ℃;

With hydrogen bromide; In water; at 20 ℃;

Reference yield: 56.0%

2,3-dihydro-1H-inden-2-amine (2975-41-9) → 5-bromo-2-aminoindane hydrobromide (321352-52-7)

Guidance literature:

With water; bromine; at 60 ℃;

DOI:10.1016/j.bmcl.2010.11.098

Reference yield:

indan-1,2,3-trione hydrate (485-47-2) + 2-aminoindane hydrochloride (2338-18-3) + isopropyl alcohol (67-63-0,8013-70-5) → 5-bromo-2-aminoindane hydrobromide (321352-52-7)

Guidance literature:

With hydrogenchloride; H₂; sodium hydroxide; sulfuric acid; bromine; hydroxylamine sulfate; acetic acid; palladium-carbon; In 5,5-dimethyl-1,3-cyclohexadiene; pentan-1-ol; water;

upstream raw materials:

indan-1,2,3-trione hydrate

2-aminoindane hydrochloride

isopropyl alcohol

2,3-dihydro-1H-inden-2-amine

Downstream raw materials:

1,1-dimethylethyl (5-bromo-2,3-dihydro-1H-inden-2-yl)carbamate

(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

(S)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

(R)-benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-2-ylcarbamate

Refernces

• 1、 Jamieson, Craig,MacLean, John K.F.,Brown, Christopher I.,Campbell, Robert A.,Gillen, Kevin J.,Gillespie, Jonathan,Kazemier, Bert,Kiczun, Michael,Lamont, Yvonne,Lyons, Amanda J.,Moir, Elizabeth M.,Morrow, John A.,Pantling, John,Rankovic, Zoran,Smith, Lynn. "Structure based evolution of a novel series of positive modulators of the AMPA receptor". scheme or table. p. 805 - 811. Retrieved 2011/02/27.
• 2、 -. "INDANE DERIVATIVES". Page/Page column 19. . Retrieved 2010/11/03.