Benzenemethanol, 2,4-difluoro-5-methyl- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 2,4-difluoro-5-methyl- (9CI)
• CAS No.: 315204-46-7
• Molecular Formula: C8H8 F2 O
• Molecular Weight: 158.148
• Hs Code.: 2906299090
• Mol file: 315204-46-7.mol

Synonyms:Benzenemethanol, 2,4-difluoro-5-methyl- (9CI)

Chemical Property of Benzenemethanol, 2,4-difluoro-5-methyl- (9CI)

Chemical Property:

• Boiling Point: 213.7±35.0 °C(Predicted)
• PKA: 13.82±0.10(Predicted)
• PSA: 20.23000
• Density: 1.236±0.06 g/cm3(Predicted)
• LogP: 1.76550

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoro-5-methylbenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 2,4-difluoro-5-methyl- (9CI)

There total 4 articles about Benzenemethanol, 2,4-difluoro-5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-difluoro-5-methyl-benzoic acid methyl ester (1162674-66-9) → (2,4-difluoro-5-methyl-phenyl)-methanol (315204-46-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 2h; Cooling with acetone-dry ice;

Reference yield: 80.0%

2,4-difluoro-5-methylbenzaldehyde (315204-36-5) → (2,4-difluoro-5-methyl-phenyl)-methanol (315204-46-7)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -10 ℃; for 1h;

DOI:10.1080/15257770008033850

Reference yield:

C7H5BrF2Mg → (2,4-difluoro-5-methyl-phenyl)-methanol (315204-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran; diethyl ether / 0.5 h / 25 °C

2: 80 percent / DIBAL-H / tetrahydrofuran / 1 h / -10 °C

With diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; 1: Grignard reaction / 2: Reduction;

DOI:10.1080/15257770008033850

upstream raw materials:

2,4-difluoro-5-methylbenzaldehyde

2,4-Difluoro-5-methylbenzoic acid

2,4-difluoro-5-methyl-benzoic acid methyl ester

Downstream raw materials:

5-(2,4-difluoro-5-methyl-benzyloxy)-2-phenyl-[1,3]dioxane

1-chloromethyl-2,4-difluoro-5-methyl-benzene

5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

1-(bromomethyl)-2,4-difluoro-5-methylbenzene

Refernces

• 1、 Wang, Zhi-Xian,Duan, Weili,Wiebe, Leonard I.,De Clercq, Erik,Balzarini, Jan,Knaus, Edward E.. "Syntheses of 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-propoxy)methyl]- derivatives of 5-substituted-2,4-Difluorobenzene: Unnatural acyclo thymidine mimics for evaluation as anticancer and antiviral agents". . p. 1397 - 1411. Retrieved 2007/10/03.