Technology Process of rac-α-tert-butoxycarbonyl-4,5-dimethoxy-2-nitrobenzyl bromide
There total 4 articles about rac-α-tert-butoxycarbonyl-4,5-dimethoxy-2-nitrobenzyl bromide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
In
tetrachloromethane;
for 20h;
Reflux;
DOI:10.1021/ja907287n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dicyclohexyl-carbodiimide; copper(l) chloride / 120 h / Inert atmosphere
1.2: 120 h / Inert atmosphere; Cooling with ice
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 20 h / Reflux; Darkness
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); dicyclohexyl-carbodiimide; copper(l) chloride;
In
tetrachloromethane;
DOI:10.1021/acs.orglett.1c02295
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; nitric acid / 3 h / 10 - 25 °C
2.1: dicyclohexyl-carbodiimide; copper(l) chloride / 120 h / Inert atmosphere
2.2: 120 h / Inert atmosphere; Cooling with ice
3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 20 h / Reflux; Darkness
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); nitric acid; acetic acid; dicyclohexyl-carbodiimide; copper(l) chloride;
In
tetrachloromethane;
DOI:10.1021/acs.orglett.1c02295
