tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate

Base Information

• Chemical Name: tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate
• CAS No.: 1196872-66-8
• Molecular Formula: C₁₄H₁₉NO₆
• Molecular Weight: 297.308
• Mol file: 1196872-66-8.mol

Synonyms:tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate

Chemical Property of tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate

There total 4 articles about tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3) + tert-butyl alcohol (75-65-0) → tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate (1196872-66-8)

Guidance literature:

tert-butyl alcohol; With dicyclohexyl-carbodiimide; copper(l) chloride; for 120h; Inert atmosphere;

(4,5-dimethoxy-2-nitrophenyl)acetic acid; In dichloromethane; for 120h; Inert atmosphere; Cooling with ice;

DOI:10.1021/acs.orglett.1c02295

Reference yield: 86.0%

(4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3) + isobutene (115-11-7,15220-85-6) → tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate (1196872-66-8)

Guidance literature:

With sulfuric acid; In dichloromethane; at -50 - 25 ℃;

DOI:10.1021/ja907287n

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate (1196872-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; nitric acid / 3 h / 10 - 25 °C

2.1: dicyclohexyl-carbodiimide; copper(l) chloride / 120 h / Inert atmosphere

2.2: 120 h / Inert atmosphere; Cooling with ice

With nitric acid; acetic acid; dicyclohexyl-carbodiimide; copper(l) chloride;

DOI:10.1021/acs.orglett.1c02295

upstream raw materials:

(4,5-dimethoxy-2-nitrophenyl)acetic acid

isobutene

N,N'-dicylohexylcarbamimidic acid tert-butyl ester

tert-butyl alcohol

Downstream raw materials:

rac-α-tert-butoxycarbonyl-4,5-dimethoxy-2-nitrobenzyl bromide

(2S)-methyl 3-(4-(2-(t-butoxy)-1-(4,5-dimethoxy-2-nitrophenyl)-2-oxoethoxy)phenyl)-2-(2,2,2-trifluoroacetamido)propanoate

(2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(2-(t-butoxy)-1-(4,5-dimethoxy-2-nitrophenyl)-2-oxoethoxy)phenyl)propanoic acid

t-butyl 2-diazo-2-(4,5-dimethoxy-2-nitrophenyl)acetate

Refernces

• 1、 Russell, Alexander G.,Sadler, Matthew J.,Laidlaw, Helen J.,Gutierrez-Loriente, Agustin,Wharton, Christopher W.,Carteau, David,Bassani, Dario M.,Snaith, John S.. "Photorelease of tyrosine from α-carboxy-6-nitroveratryl (αCNV) derivatives". experimental part. p. 556 - 563. Retrieved 2012/06/30.