N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine

Base Information

• Chemical Name: N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine
• CAS No.: 219840-92-3
• Molecular Formula: C₂₃H₂₆BrN₃
• Molecular Weight: 424.384
• Mol file: 219840-92-3.mol

Synonyms:N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine

Chemical Property of N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine

There total 4 articles about N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-isopropylaniline (51605-97-1) + 2-chloro-6-methyl-4-(2,4,6-trimethylphenyl)pyrimidine (219840-91-2) → N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine (219840-92-3)

Guidance literature:

With ethylene glycol; Heating;

DOI:10.1016/S0960-894X(99)00132-8

Reference yield:

2-chloro-4-methylpyrimidine (13036-57-2) + 2,4,6-trimethylphenyl bromide (576-83-0) → N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine (219840-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butyl lithium; acetic acid / tetrahydrofuran; hexane; water; ethyl acetate

2: hexane; ethylene glycol; ethyl acetate

With tert.-butyl lithium; acetic acid; In tetrahydrofuran; hexane; water; ethylene glycol; ethyl acetate;

Reference yield:

2-chloro-4-methylpyrimidine (13036-57-2) → N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine (219840-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) DDQ / 1.) ether, from -30 deg C to 0 deg C, 2.) ether, THF, 0 deg C

2: ethylene glycol / Heating

With ethylene glycol; 2,3-dicyano-5,6-dichloro-p-benzoquinone;

DOI:10.1016/S0960-894X(99)00132-8

upstream raw materials:

2-bromo-4-isopropylaniline

2-chloro-6-methyl-4-(2,4,6-trimethylphenyl)pyrimidine

2-chloro-4-methylpyrimidine

mesityllithium

Refernces

• 1、 Cocuzza, Anthony J.,Hobbs, Frank W.,Arnold, Charles R.,Chidester, Dennis R.,Yarem, Jerry A.,Culp, Steven,Fitzgerald, Lawrence,Gilligan, Paul J.. "4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists". . p. 1057 - 1062. Retrieved 2007/10/03.