2-BROMO-4-ISOPROPYLANILINE

Base Information

• Chemical Name: 2-BROMO-4-ISOPROPYLANILINE
• CAS No.: 51605-97-1
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Hs Code.: 2921420090
• Mol file: 51605-97-1.mol

Synonyms:Cumidine,2-bromo- (6CI);2-Bromo-4-(1-methylethyl)benzenamine;2-Bromo-4-isopropylaniline;2-Bromo-4-isopropylphenylamine;

Chemical Property of 2-BROMO-4-ISOPROPYLANILINE

Chemical Property:

• Vapor Pressure: 0.00631mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 271.8 °C at 760 mmHg
• PKA: 2.94±0.10(Predicted)
• Flash Point: 118.2 °C
• PSA: 26.02000
• Density: 1.355 g/cm³
• LogP: 3.73590
• Storage Temp.: Room temperature.
• Water Solubility.: Miscible with dioxane and ethoxyethanol. Immiscible with water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-4-isopropylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-4-isopropylaniline is involved in the preparation of 4-(5-aryl-1, 2, 3, 6-tetrahydropyridino) pyrimidine derivatives and 4-substituted-2-anilinopyrimidine derivatives, which find application as corticotropin releasing factor (CRF) antagonists.

Technology Process of 2-BROMO-4-ISOPROPYLANILINE

There total 3 articles about 2-BROMO-4-ISOPROPYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Isopropylaniline (99-88-7) → 2-bromo-4-isopropylaniline (51605-97-1)

Guidance literature:

With N-Bromosuccinimide; methyl 2-n-pentyl-1H-indole-3-carboxylate; In n-heptane; at 23 ℃; for 24h; regioselective reaction; Darkness; Green chemistry;

DOI:10.1039/c8gc02415d

Reference yield:

N-(4-iso-propylphenyl)acetamide (5702-74-9) → 2-bromo-4-isopropylaniline (51605-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine

2: aq.-ethanolic hydrochloric acid

With hydrogenchloride; bromine; acetic acid;

DOI:10.1021/jo01213a003 DOI:10.1039/jr9390001299

Reference yield:

→ 2-bromo-4-isopropylaniline (51605-97-1)

Guidance literature:

aus 4-Amino-isopropyl-benzol, 1) sied. Ac2O(5h), 2) Br2 in Eg. bei 40-50grad, 3) wss.aethanol.HCl unter Rueckfluss(4h);

upstream raw materials:

4-Isopropylaniline

N-(4-iso-propylphenyl)acetamide

Downstream raw materials:

1-bromo-3-isopropylbenzene

4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-chloro-2-methylpyrimidine-4,5-diamine

2-bromo-4-isopropylphenylisothiocyanate

N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine

Refernces

• 1、 -. "ANTIHYPERTENSIVE POLYOL COMPOUND AND DERIVATIVE THEREOF". Paragraph 0096-0097. . Retrieved 2021/11/14.
• 2、 -. "INDANYL COMPOUNDS AS VOLTAGE GATED SODIUM CHANNEL MODULATORS". Page/Page column 63. . Retrieved 2018/09/28.