C₁₂H₁₆FNO

Base Information

• Chemical Name: C₁₂H₁₆FNO
• CAS No.: 1338722-52-3
• Molecular Formula: C₁₂H₁₆FNO
• Molecular Weight: 209.264
• Mol file: 1338722-52-3.mol

Synonyms:C₁₂H₁₆FNO

Chemical Property of C₁₂H₁₆FNO

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₁₂H₁₆FNO

There total 1 articles about C₁₂H₁₆FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-3-fluorophenol (399-95-1) + 4-methyl-2-pentanone (108-10-1) → C12H16FNO (1338722-52-3)

Guidance literature:

Reflux;

Reference yield:

C12H16FNO (1338722-52-3) + 4-chloro-N-methylpicolinamide (220000-87-3) → 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide (757251-39-1)

Guidance literature:

C₁₂H₁₆FNO; 4-chloro-N-methylpicolinamide; In 1-methyl-pyrrolidin-2-one; at 100 ℃;

With potassium tert-butylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 4.16667h;

With acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; toluene; at 80 ℃; for 0.166667h;

Reference yield:

C12H16FNO (1338722-52-3) → regorafenib (755037-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 100 °C

1.2: 4.17 h / 100 °C

1.3: 0.17 h / 80 °C

2.1: toluene; tetrahydrofuran / 4.5 h / 20 °C

2.2: 2.25 h

In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;

upstream raw materials:

4-amino-3-fluorophenol

4-methyl-2-pentanone

Downstream raw materials:

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

regorafenib

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF 4- {4-[({[4 -CHLORO-3 -(TRIFLUOROMETHYL)-PHENYL]AMINO}CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE". Page/Page column 14. . Retrieved 2011/11/01.