γ-phenyl-γ-hydroxybutyric acid methylester

Base Information

• Chemical Name: γ-phenyl-γ-hydroxybutyric acid methylester
• CAS No.: 126252-15-1
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol file: 126252-15-1.mol

Synonyms:γ-phenyl-γ-hydroxybutyric acid methylester

Chemical Property of γ-phenyl-γ-hydroxybutyric acid methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of γ-phenyl-γ-hydroxybutyric acid methylester

There total 21 articles about γ-phenyl-γ-hydroxybutyric acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(Z)-4-Hydroxy-4-phenyl-but-2-enoic acid methyl ester → γ-phenyl-γ-hydroxybutyric acid methylester (126252-15-1)

Guidance literature:

With methanol; sodium tetrahydroborate; at -34 ℃;

DOI:10.1021/ol0495366

Reference yield: 100.0%

→ (R)-methyl 4-hydroxy-4-phenylbutanoate (99512-38-6,111044-00-9,126252-15-1,99613-37-3)

Guidance literature:

Reference yield: 95.0%

3-benzoylpropionic acid methyl ester (25333-24-8) → (R)-methyl 4-hydroxy-4-phenylbutanoate (99512-38-6,111044-00-9,126252-15-1,99613-37-3)

Guidance literature:

With borane-THF; (S)-Me-CBS; In tetrahydrofuran; toluene; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)01877-9

upstream raw materials:

acrylic acid methyl ester

benzyl alcohol

diazomethane

4,5-dihydro-5-phenyl-2(3H)-furanone

Downstream raw materials:

methanol

(2S)-N-allyl-2-phenylpyrrolidine

C₂₇H₃₅N

(S)-2-phenylpyrrolidine

Refernces

• 1、 ??d?o-Dobrowolska, Anna,Borowiecki, Pawe?,Heider, Johann,Kroutil, Wolfgang,Reiter, Tamara,Schühle, Karola,Szaleniec, Maciej,Tataruch, Mateusz,Telatycka, Natalia. "Biocatalytic Asymmetric Reduction of γ-Keto Esters to Access Optically Active γ-Aryl-γ-butyrolactones". . . Retrieved 2020/04/20.
• 2、 Periasamy, Mariappan,Sanjeevakumar, Nalluri,Dalai, Manasi,Gurubrahamam, Ramani,Reddy, Polimera Obula. "Highly enantioselective synthesis of chiral allenes by sequential creation of stereogenic center and chirality transfer in a single pot operation". supporting information; experimental part. p. 2932 - 2935. Retrieved 2012/08/28.