Technology Process of 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine
There total 8 articles about 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium acetate; sodium iodide;
In
dimethyl sulfoxide;
at 70 ℃;
for 50h;
DOI:10.1002/jhet.5570260247
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 8.7 percent / dimethylsulfoxide / 0.33 h / Heating
2: 62 percent / 1 N HCl, H2 / 10 percent Pd/C / propan-2-ol; H2O
3: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C
With
hydrogenchloride; hydrogen; sodium acetate; sodium iodide;
palladium on activated charcoal;
In
water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1002/jhet.5570260247
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 73 percent / POCl3, DMF / 3.5 h / Heating
2: 71 percent / NH2NH2 / H2O; ethanol / 17 h / Ambient temperature
3: 81 percent / 1 N HCl, H2 / 10 percent Pd/C / ethanol
4: 92 percent / H2 / Davison sponge nickel / ethanol; H2O / 22 h
5: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C
With
hydrogenchloride; hydrogen; sodium acetate; N,N-dimethyl-formamide; sodium iodide; hydrazine; trichlorophosphate;
palladium on activated charcoal; Davison sponge nickel;
In
ethanol; water; dimethyl sulfoxide;
DOI:10.1002/jhet.5570260247