(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate

Base Information

• Chemical Name: (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate
• CAS No.: 345649-43-6
• Molecular Formula: C₁₅H₁₆Cl₂N₂O₅S
• Molecular Weight: 407.274
• Mol file: 345649-43-6.mol

Synonyms:(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate

Chemical Property of (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate

There total 1 articles about (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + cis-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-4-hydroxymethyl-1,3-dioxolane (170210-49-8) → (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate (345649-43-6)

Guidance literature:

With pyridine;

Reference yield: 81.0%

(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate (345649-43-6) + 1-(4-hydroxy-3,5-dimethylphenyl)-4-(6-(2-cyclopentylethyl)-2-ethylpyrimidin-4-yl)piperazine → 2-S,(R)-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-4-R,(S)-[(4-(4-(6-(2-cyclopentylethyl)-2-ethylpyrimidin-4-yl)piperazin-1-yl)-2,6-dimethylphenoxy)methyl]-1,3-dioxolane

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In toluene;

Reference yield: 76.0%

(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate (345649-43-6) + 6-hydroxy-2-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline (94085-68-4) → 6-[(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyloxy]-2-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With tetrabutylammomium bromide; In methanol; water; ethyl acetate; toluene;

upstream raw materials:

methanesulfonyl chloride

cis-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-4-hydroxymethyl-1,3-dioxolane

Downstream raw materials:

N-{4-[2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-acetamide

1-(4-{4-[2-(2,4-dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-ethanone

Refernces

• 1、 -. "1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles". . . Retrieved 2008/06/13.