Technology Process of (6R)-5,10-methylylidenetetrahydrofolic acid chloride
There total 7 articles about (6R)-5,10-methylylidenetetrahydrofolic acid chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
at 25 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 77 percent / 50 percent NaOH, sodium dithionite / H2O / 3.33 h / Ambient temperature
2: NaOH, EDTA, MgCl2*6H2O, dithiotreitol, adenosine triphosphate, glucose hydrate, NADP(1+), diammonium acetyl phosphate / H2O / 168 h / Ambient temperature; protection from light; enzyme-catalyzed reduction with dihydrofolate reductase, glucose 6-phosphate dehydrogenase hexokinase and acetate kinase
3: 24 percent / 1 M HCl / trifluoroacetic acid; H2O / 14 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; sodium dithionite; D-glucose monohydrate; ethylenediaminetetraacetic acid; acetyl diammonium phosphate; nicotinamide adenine dinucleotide phosphate; ATP; magnesium chloride; diothiothreitol;
In
water; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)87409-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaOH, EDTA, MgCl2*6H2O, dithiotreitol, adenosine triphosphate, glucose hydrate, NADP(1+), diammonium acetyl phosphate / H2O / 168 h / Ambient temperature; protection from light; enzyme-catalyzed reduction with dihydrofolate reductase, glucose 6-phosphate dehydrogenase hexokinase and acetate kinase
2: 24 percent / 1 M HCl / trifluoroacetic acid; H2O / 14 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; D-glucose monohydrate; ethylenediaminetetraacetic acid; acetyl diammonium phosphate; nicotinamide adenine dinucleotide phosphate; ATP; magnesium chloride; diothiothreitol;
In
water; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)87409-3
