2-[(4-methylphenyl)ethynyl]benzoxazole

Base Information

• Chemical Name: 2-[(4-methylphenyl)ethynyl]benzoxazole
• CAS No.: 1187772-35-5
• Molecular Formula: C₁₆H₁₁NO
• Molecular Weight: 233.269
• Mol file: 1187772-35-5.mol

Synonyms:2-[(4-methylphenyl)ethynyl]benzoxazole

Chemical Property of 2-[(4-methylphenyl)ethynyl]benzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-methylphenyl)ethynyl]benzoxazole

There total 7 articles about 2-[(4-methylphenyl)ethynyl]benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

benzoxazole (273-53-0,29791-96-6) + 4-n-methylphenylacetylene (766-97-2) → 2-[(4-methylphenyl)ethynyl]benzoxazole (1187772-35-5)

Guidance literature:

With Pd(II)(N-(3-(1-hydroxy-3-phenylpropan-2-yl carbamoyl)benzylidene)-2-methylpropan-2-amineoxide(-2H)); caesium carbonate; silver(l) oxide; In N,N-dimethyl-formamide; at 85 ℃; for 8h;

DOI:10.1016/j.tet.2015.02.020

Reference yield: 70.0%

benzoxazole (273-53-0,29791-96-6) + 1-(2-bromoethynyl)-4-methylbenzene (33491-05-3) → 2-[(4-methylphenyl)ethynyl]benzoxazole (1187772-35-5)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; o-phenylenebis(diphenylphosphine); lithium tert-butoxide; In toluene; for 1h; Reflux; Inert atmosphere;

DOI:10.1021/ol901684h

Reference yield: 60.0%

2-methylsulfanyl-benzoxazole (13673-62-6) + 4-n-methylphenylacetylene (766-97-2) → 2-[(4-methylphenyl)ethynyl]benzoxazole (1187772-35-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine; In toluene; for 24h; Reflux;

DOI:10.1016/j.tetlet.2015.08.001

upstream raw materials:

benzoxazole

1-(2-bromoethynyl)-4-methylbenzene

4-n-methylphenylacetylene

1-(2,2-dichlorovinyl)-4-methylbenzene

Refernces

• 1、 Srivastava, Ananya,Aggarwal, Leena,Jain, Nidhi. "One-pot sequential alkynylation and cycloaddition: Regioselective construction and biological evaluation of novel benzoxazole-triazole derivatives". . p. 39 - 48. Retrieved 2015/01/30.
• 2、 Theunissen, Cdric,Evano, Gwilherm. "Room-temperature direct alkynylation of arenes with copper acetylides". supporting information. p. 4488 - 4491. Retrieved 2015/01/09.