N-formyl-noratropine

Base Information

• Chemical Name: N-formyl-noratropine
• CAS No.: 119293-48-0
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 303.358
• Mol file: 119293-48-0.mol

Synonyms:N-formyl-noratropine

Chemical Property of N-formyl-noratropine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-formyl-noratropine

There total 3 articles about N-formyl-noratropine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

formic acid (64-18-6) + Noratropine (16839-98-8) → N-formyl-noratropine (119293-48-0)

Guidance literature:

formic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.25h; Cooling with ice;

Noratropine; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1039/c3gc41972j

Reference yield:

Atropine (51-55-8) → N-formyl-noratropine (119293-48-0) + Noratropine (16839-98-8)

Guidance literature:

With oxygen; 9,10-Dicyanoanthracene; In acetonitrile; at 20 ℃; Irradiation;

DOI:10.1016/S0040-4039(00)99299-2

Reference yield:

Atropine (51-55-8) → N-formyl-noratropine (119293-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Na[(TAML)Fe(III)]; dihydrogen peroxide / ethanol; water / 1 h / -40 - -20 °C

2.1: Na[(TAML)Fe(III)] / ethanol / 0.08 h

2.2: 1 h

With Na[(TAML)Fe(III)]; dihydrogen peroxide; In ethanol; water;

DOI:10.1039/c3gc41972j

upstream raw materials:

Atropine

formic acid

Noratropine

Refernces

• 1、 -. "MEANS AND METHODS FOR THE N-DEALKYLATION OF AMINES". Page/Page column 21. . Retrieved 2017/11/10.