2,4-dichlorophenyl 4′-nitrophenyl sulfide

Base Information

• Chemical Name: 2,4-dichlorophenyl 4′-nitrophenyl sulfide
• CAS No.: 42583-60-8
• Molecular Formula: C₁₂H₇Cl₂NO₂S
• Molecular Weight: 300.165
• Mol file: 42583-60-8.mol

Synonyms:2,4-dichlorophenyl 4′-nitrophenyl sulfide

Chemical Property of 2,4-dichlorophenyl 4′-nitrophenyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichlorophenyl 4′-nitrophenyl sulfide

There total 4 articles about 2,4-dichlorophenyl 4′-nitrophenyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-dichlorobenzenethiol (1122-41-4) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2,4-dichlorophenyl 4′-nitrophenyl sulfide (42583-60-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 99.0%

p-nitrobenzene iodide (636-98-6) + 2,4-dichlorobenzenethiol (1122-41-4) → 2,4-dichlorophenyl 4′-nitrophenyl sulfide (42583-60-8)

Guidance literature:

With potassium phosphate; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In butan-1-ol; at 120 ℃; for 2h; Microwave irradiation;

DOI:10.1002/jccs.201190064

Reference yield: 58.0%

2,4-dichlorobenzenethiol (1122-41-4) + 4-chlorobenzonitrile (100-00-5) → 2,4-dichlorophenyl 4′-nitrophenyl sulfide (42583-60-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 3h; Heating;

DOI:10.1021/jm00386a004

upstream raw materials:

p-nitrobenzene iodide

2,4-dichlorobenzenethiol

4-chlorobenzonitrile

2,4-Dichlorobenzenesulfonyl chloride

Downstream raw materials:

4-(2,4-dichloro-benzenesulfonyl)-aniline; hydrochloride

4-(2,4-dichlorobenzenesulfonyl)phenylamine

4-(2,4-dichloro-phenylsulfanyl)-aniline; hydrochloride

2,4-dichloro-1-(4-nitrobenzenesulfonyl)benzene

Refernces

• 1、 Bagley, Mark C.,Fusillo, Vincenzo,Hills, Edward G.B.,Mulholland, Alex T.,Newcombe, Joseph,Pentecost, Leanne J.,Radley, Emily L.,Stephens, Bethan R.,Turrell, Christopher C.. "Microwave-assisted Ullmann-Buchwald C-S bond formation using a copper(I) catalyst and trans-cyclohexane-1,2-diol as ligand". . p. 294 - 313. Retrieved 2013/01/16.
• 2、 Benedetti, Pier G. De,Iarossi, Dario,Menziani, Cristina,Caiolfa, Valeria,Frassineti, Chiara,Cennamo, Carlo. "Quantitative Structure-Activity Analysis in Dihydropteroate Synthase Inhibition by Sulfones. Comparison with Sulfanilamides". . p. 459 - 464. Retrieved 2007/10/02.