C₁₉H₁₇F₃N₄OS

Base Information

• Chemical Name: C₁₉H₁₇F₃N₄OS
• CAS No.: 1581726-25-1
• Molecular Formula: C₁₉H₁₇F₃N₄OS
• Molecular Weight: 406.431
• Mol file: 1581726-25-1.mol

Synonyms:C₁₉H₁₇F₃N₄OS

Chemical Property of C₁₉H₁₇F₃N₄OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₉H₁₇F₃N₄OS

There total 6 articles about C₁₉H₁₇F₃N₄OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H25F3N4O3S (1581726-24-0) → C19H17F3N4OS (1581726-25-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2014.01.075

Reference yield:

2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (104960-49-8) → C19H17F3N4OS (1581726-25-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / N,N-dimethyl-formamide; water / 20 °C

2: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.01.075

Reference yield:

ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester (299165-10-9) → C19H17F3N4OS (1581726-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2014.01.075

upstream raw materials:

2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

3-amino-2-carboxy-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine

C₂₄H₂₅F₃N₄O₃S

ethyl 3-amino-6-phenyl-4-trifluoromethylthiophene[2,3-b]pyridine-2-ethyl ester

Refernces